The histone‐like protein HU is a highly abundant DNA architectural protein that is involved
in compacting the DNA of the bacterial nucleoid and in regulating the main DNA …

In contrast to organized hierarchical structure of eukaryotic chromosome, bacterial
chromosomes are believed not to have such structures. The genomes of bacteria are …

In bacteria, the contribution of global nucleoid organization in determining cellular
transcription programs is unclear. Using a mutant form of the most abundant nucleoid …

HU (Histone‐like protein from Escherichia coli strain U93) is the most conserved nucleoid‐
associated protein in eubacteria, but how it impacts global chromosome organization is …

Bacterial nucleoid organization is believed to have minimal influence on the global
transcription program. Using an altered bacterial histone-like protein, HUα, we show that …

In bacteria, chromosomal DNA must be efficiently compacted to fit inside the small cell
compartment while remaining available for the proteins involved in replication, segregation …

Bacterial histone-like HU proteins are critical to maintenance of the nucleoid structure. In
addition, they participate in all DNA-dependent functions, including replication, repair …

The extent to which chromosomal gene position in prokaryotes affects local gene expression
remains an open question. Several studies have shown that chromosomal re-positioning of …

Escherichia coli hupA hupB double mutants, lacking both subunits (HU1 and HU2) of the
histone-like protein HU, accumulate secondary mutations. In some genetic backgrounds …

Molecular mechanisms controlling functional bacterial chromosome (nucleoid) compaction
and organization are surprisingly enigmatic but partly depend on conserved, histone-like …