The bacterial chromosome is organized into loops, which constitute topologically isolated
domains. It is unclear which proteins are responsible for the formation of the topological …

Extremely AT-rich DNA sequences present a challenging template for specific recognition by
RNA polymerase. In bacteria, this is because the promoter− 10 hexamer, the major DNA …

Cellular adaptation to changing environmental conditions requires the coordinated
regulation of expression of large sets of genes by global regulatory factors such as nucleoid …

Structural differentiation of bacterial chromatin depends on cooperative binding of abundant
nucleoid-associated proteins at numerous genomic DNA sites and stabilization of distinct …

The dimeric histone-like protein HU, one of the most abundant DNA binding proteins
ofEscherichia coli, is encoded by two closely related but unlinked genes, hupAandhupB …

The histone-like nucleoid structuring (H-NS) protein is a major component of the folded
chromosome in Escherichia coli and related bacteria. Functions attributed to H-NS include …

Controlling the size and shape of DNA condensates is important in vivo and for the
improvement of nonviral gene delivery. Here, we demonstrate that the morphology of DNA …

The packaging of nuclear DNA by histones into nucleosomes and chromatin is a feature as
definitive of the Eucarya as the nuclear membrane, and determining how eucaryal RNA …

IHF and HU are two heterodimeric nucleoid-associated proteins (NAP) that belong to the
same protein family but interact differently with the DNA. IHF is a sequence-specific DNA …

Recent studies have revealed that the bacterial nucleoid is a dynamic entity that alters its
overall structure in response to changes in both growth rate and growth phase. These …