Peroxisomes require peroxin (Pex) proteins for their biogenesis. The interaction between
Pex3p, which resides on the peroxisomal membrane, and Pex19p, which resides in the …

We isolated peroxisome biogenesis mutants ZP128 and ZP150 from rat PEX2-transformed
Chinese hamster ovary (CHO) cells, by the 9-(1′-pyrene) nonanol/ultraviolet method. The …

The endoplasmic reticulum (ER) is required for the de novo biogenesis of peroxisomes in
mammalian cells. However, its role in peroxisome maintenance is unclear. To explore ER …

During de novo peroxisome biogenesis, importomer complex proteins sort via two
preperoxisomal vesicles (ppVs). However, the sorting mechanisms segregating peroxisomal …

The present review summarizes recent observations on binding of Arf and COPI coat to
isolated rat liver peroxisomes. The general structural and functional features of both Arf and …

Proteins are targeted to the membrane and matrix of peroxisomes by distinct pathways.
Recent observations suggest a further route: a subset of peroxisomal membrane proteins …

The PEX11 peroxisomal membrane proteins are the only factors known to promote
peroxisome division in multiple species. It has been proposed that PEX11 proteins have a …

The peroxin Pex19p comprising 299 amino acids functions in peroxisomal membrane
assembly. We here developed a cell-free system for transport of membrane proteins to …

Peroxisomes are eukaryotic organelles that are the subcellular location of important
metabolic reactions. In humans, defects in the organelle's function are often lethal. Yet …

Human PEX5 and PEX14 are essential components of the peroxisomal translocon, which
mediates import of cargo enzymes into peroxisomes. PEX5 is a soluble receptor for cargo …