The mechanism of radiogallium uptake into tumor in vivo has been investigated using the
canine transmissible venereal tumor (TVT) as a model. The blood clearance and uptake in …

Different gallium-transferrin-anion complexes (nitrilotriacetate, maleate, malonate and
oxalate) were investigated to determine the effect of such anion complexes on gallium-67 …

When injected at tracer levels into the blood, radiogallium binds to plasma transferrin and is
transported to the tumor tissue. The mechanism, however, by which this transferrin-bound …

In certain animal tumor systems, transferrin appears to play a key role in the cellular uptake
of radiogallium. This process is mediated by a transferrin receptor which is present on tumor …

Human melanoma cells were incubated with 67 Ga-citrate, a mixture of 67 Ga-citrate and
transferrin, 67 Ga-transferrin and 67 Ga-transferrin-125 I. It was found that there was a …

When injected at tracer levels into the blood, radiogallium as 67 Ga-citrate binds to, and is
transported to the site of the tumor by, transferrin. The process by which transferrin-bound …

As a crucial step toward the understanding of the tumor localization of gallium, we have re-
investigated its binding and transport in blood. The studies were performed in vivo by …

The EMT-6 sarcoma-like tumor of BALBIc mice can be grown as a solid subcuta neous
transplantable tumor in vivo or as a monolayer culture in vitro. We have studied the uptake of …

The biodistribution of 67Gafor the various groups of mice, expressed as percent injected
dose per gram of tissue (% ID/g), are summarized in Table 1. The tissueto-blood and tumor …

INVESTIGATIVE NUCLEAR MEDICINE A Transferrin-Mediated Uptake of Gallium-67 by EMT-6
Page 1 CLINICAL SCIENCES Nearly a decade has passed since Hayes and Ed wards observed …