Tumour necrosis factor gene polymorphism and disease prevalence

T Qidwai, F Khan - Scandinavian journal of immunology, 2011 - Wiley Online Library
Tumour necrosis factor (TNF), an important proinflammatory cytokine, plays a role in the
regulation of cell differentiation, proliferation and death, as well as in inflammation, innate …

A common functional polymorphism (C→ A substitution at position− 863) in the promoter region of the tumour necrosis factor-α (TNF-α) gene associated with reduced …

T Skoog, FM van't Hooft, B Kallin… - Human molecular …, 1999 - academic.oup.com
Tumour necrosis factor-α (TNF-α) plays a key role in orchestrating the complex events
involved in inflammation and immunity. Accordingly, TNF-α has been implicated in a wide …

Genetics of tumour necrosis factor-alpha in autoimmune, infectious, and neoplastic diseases.

AG Wilson, FS Di Giovine, GW Duff - Journal of inflammation, 1995 - europepmc.org
Tumour necrosis factor-alpha (TNF-alpha) is a potent immunomediator and proinflammatory
cytokine that has been implicated in the pathogenesis of a large number of human diseases …

[HTML][HTML] Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): implications of its allelic distribution on susceptibility or …

J Cuenca, CA Pérez, AJ Aguirre, I Schiattino… - Biological …, 2001 - SciELO Chile
Several single-nucleotide polymorphisms have been identified in the human TNF gene
promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A …

Polymorphisms of tumour necrosis factors A and B in breast cancer

KS Park, JW Mok, HE Ko, K Tokunaga… - European journal of …, 2002 - Wiley Online Library
We assayed for germline single nucleotide polymorphisms (SNPs) in the TNFB and TNFA
genes in patients with breast cancer. SNPs were observed in the first intron of TNFB (G/A) …

Influence of TNFα gene polymorphisms on TNFα production and disease

AH Hajeer, IV Hutchinson - Human immunology, 2001 - Elsevier
Tumor necrosis factor α (TNFα) is a potent inflammatory cytokine. In human, the TNFα gene
is located within the highly polymorphic major histocompatibility complex (MHC) region on …

[HTML][HTML] Tumor necrosis factor alpha− 308 gene locus promoter polymorphism: an analysis of association with health and disease

MM Elahi, K Asotra, BM Matata, SS Mastana - Biochimica et Biophysica …, 2009 - Elsevier
Tumor necrosis factor-alpha (TNF-α) is a potent immunomediator and proinflammatory
cytokine that has been implicated in the pathogenesis of a large number of human diseases …

TNF-α gene polymorphisms and expression

RR El-Tahan, AM Ghoneim, N El-Mashad - Springerplus, 2016 - Springer
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in
the pathogenesis of several diseases. Its encoding gene is located in the short arm of …

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino …

G Messer, U Spengler, MC Jung, G Honold… - The Journal of …, 1991 - rupress.org
Since a dysregulated synthesis of tumor necrosis factor alpha (TNF-alpha) may be involved
in the pathogenesis of autoimmune diseases, it was of interest to precisely locate the …

Functional study of TNF-α promoter polymorphisms: literature review and meta-analysis

A Mekinian, R Tamouza, S Pavy, N Gestermann… - European cytokine …, 2011 - jle.com
4. Kaijzel EL, Bayley JP, Smith L, Van de Linde P, Bakker AM, Verweij CL Allele-specific
quantification of tumour necrosis factor alpha transcription and the role of promoter …