Abstract Background Water extract of Hydrangea paniculata (HP) stem, rich in coumarin
glycosides, has been demonstrated to have renal protective effect in several experimental …

Diabetic nephropathy is a major complication of diabetes mellitus and is related to
dysfunction of renal cells. Hederagenin is a triterpenoid saponin from some Chinese herbs …

Background Total coumarins extracted from Hydrangea. Paniculata, Sieb (HP) have showed
renal protective effect in several experimental acute and chronic kidney diseases. Purpose …

Diabetic nephropathy is a progressive kidney disease resulting from long-term
hyperglycaemia in diabetic patients, and the underlying mechanism is complex and lacks …

Catalpol is an iridoid glycoside compound isolated from the root of Rehmannia glutinosa,
which has been reported to be a promising candidate for the treatment of diabetic diseases …

We previously reported that Hibiscus sabdariffa polyphenol extracts (HPE) are beneficial for
diabetic nephropathy. Since an epithelial to mesenchymal transition (EMT) is critical in renal …

Background Owing to the multiple causative factors, the current advances in medication for
diabetic nephropathy (DN) do not appear to have improved therapies for patients …

Background Kaempferol is a natural polyflavonol that has gained considerable attention as
antidiabetic therapeutics. Recent reports emphasize the role of hyperglycemia and …

The spontaneous db/db mice were used to elucidate the biological effects and mechanisms
of Rehmannia glutinosa leaves total glycoside (DHY) on kidney injury through biochemical …

The epithelial to mesenchymal transition (EMT) is important in renal fibrosis. Ser307
phosphorylation of insulin receptor substrate-1 (IRS-1 (S307)) is a hallmark of insulin …