Background Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine with both anti-
tumorigenic and pro-tumorigenic activity, affecting tumor cell biology, the balance between …

Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma
and the senescence-associated secretory phenotype (SASP) can affect tumor growth and …

Melanoma is the most lethal form of human skin cancer. However, only limited
chemotherapy is currently available for the metastatic stage of the disease. Since …

Research on mitochondrial fusion and fission (mitochondrial dynamics) has gained much
attention in recent years, as it is important for understanding many biological processes …

Although T cell checkpoint inhibitors have transformed the treatment of cancer, the
molecular determinants of tumor cell sensitivity to T cell–mediated killing need further …

Increasing chronological age is the most significant risk factor for cancer. Recently, we
proposed a new paradigm for understanding the role of the aging and the tumor …

Cellular senescence provides a biological barrier against tumor progression, often
associated with oncogene-induced replication and/or oxidative stress, cytokine production …

Head and neck squamous cell carcinoma (HNSCC) remains one of the most common
malignancies worldwide. Although the treatment outcomes of HNSCC have improved in …

Reactive oxygen species (ROS) are emerging as important regulators of cancer growth and
metastatic spread. However, how cells integrate redox signals to affect cancer progression is …

TNF affects many cellular metabolic processes, regulates gene expression, and may induce
apoptosis or necrosis dependent on cell type and conditions of exposure. TNF also induces …