Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations

C Ma, J Zhang, D Tang, X Ye, J Li, N Mu, Z Li… - Frontiers in …, 2020 - frontiersin.org
Background: The significance of uncommon epidermal growth factor receptor (EGFR)
mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) …

EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer

AF Eichler, KT Kahle, DL Wang, VA Joshi… - Neuro …, 2010 - academic.oup.com
A small subset of patients with nonsmall cell lung cancer (NSCLC) harbors mutations in the
epidermal growth factor receptor (EGFR) that predict unique sensitivity to EGFR tyrosine …

EGFR mutation status and its impact on survival of Chinese non-small cell lung cancer patients with brain metastases

D Luo, X Ye, Z Hu, K Peng, Y Song, X Yin, G Zhu, Q Ji… - Tumor Biology, 2014 - Springer
Brain metastasis (BM) is a leading cause of death in patients with non-small cell lung cancer
(NSCLC). EGFR mutations in primary NSCLC lesions have been associated with sensitivity …

Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study

YH Chen, YF Chen, CY Chen, JY Shih, CJ Yu - BMC cancer, 2019 - Springer
Background Non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor
receptor (EGFR) mutations often develop brain metastases. Treatment with EGFR-tyrosine …

High probability and frequency of EGFR mutations in non-small cell lung cancer with brain metastases

M Ge, Y Zhuang, X Zhou, R Huang, X Liang… - Journal of neuro …, 2017 - Springer
Lung cancer is the leading cause of cancer death in men and women worldwide. Brain
metastasis (BMs) of non-small cell lung cancer (NSCLC) is the most important cause of …

Impacts of EGFR mutation and EGFR-TKIs on incidence of brain metastases in advanced non-squamous NSCLC

BX Wang, W Ou, XY Mao, Z Liu, HQ Wu… - Clinical Neurology and …, 2017 - Elsevier
Objective Brain metastases remain lethal in lung cancer patients. The impacts of epidermal
growth factor receptor (EGFR) mutations and EGFR tyrosine kinase inhibitors (TKIs) on the …

EGFR mutation status in brain metastases of non-small cell lung carcinoma

F Burel-Vandenbos, D Ambrosetti, M Coutts… - Journal of neuro …, 2013 - Springer
Brain metastases are a frequent and grave complication of non-small cell lung carcinoma
(NSCLC). The prognosis is generally poor, despite standard therapy based on surgery and …

The effectiveness of EGFR-TKIs against brain metastases in EGFR mutation-positive non-small-cell lung cancer

H Bai, B Han - OncoTargets and therapy, 2017 - Taylor & Francis
Brain metastases are usual in non-small-cell lung cancer (NSCLC) with poor prognosis and
few available therapeutic options. This retrospective study aims to evaluate the efficacy of …

Epidermal growth factor receptor mutations and brain metastases in non-small cell lung cancer

W Zhao, W Zhou, L Rong, M Sun, X Lin, L Wang… - Frontiers in …, 2022 - frontiersin.org
Studies have revealed that non-small cell lung cancer (NSCLC) with epidermal growth factor
receptor (EGFR) mutations has a high incidence of brain metastases (BMs). However, the …

Brain metastasis, EGFR mutation subtype and generation of EGFR-TKI jointly influence the treatment outcome of patient with EGFR-mutant NSCLC

JS Ju, ACC Huang, PH Tung, CH Huang, TH Chiu… - Scientific Reports, 2023 - nature.com
Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation
is brain metastasis (BM)-prone. We determined the impact of this hallmark, along with EGFR …