[HTML][HTML] Does smoking alter the mutation profile of human papillomavirus–driven head and neck cancers?

H Mirghani, L Lacroix, C Rossoni, R Sun… - European Journal of …, 2018 - Elsevier
Background Human papillomavirus (HPV)-driven oropharyngeal cancer (OPC) patients are
characterised by a better prognosis than their HPV-negative counterparts. However, this …

Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma

AC de Carvalho, S Perdomo, W Dos Santos… - Scientific Reports, 2020 - nature.com
Tobacco-or human papillomavirus-driven oropharyngeal squamous cell carcinomas
(OpSCC) represent distinct clinical, biological and epidemiological entities. The aim of this …

Molecular profile of human papillomavirus–positive oropharyngeal squamous cell carcinoma stratified by smoking status

JP Zevallos, E Yim, P Brennan, AY Liu… - International Journal of …, 2016 - redjournal.org
Results Sixty-six HPV-positive OPSCC cases were examined, including 40 HPV+ OPSCC>
10 pack-year and 26 HPV+< 10 pack-year smokers. Disease-free and overall survival were …

Smoking impact on HPV driven head and neck cancer's oncological outcomes?

H Mirghani, C Leroy, Y Chekourry, O Casiraghi… - Oral oncology, 2018 - Elsevier
Introduction HPV-driven oropharyngeal cancer (OPC) patients have a better prognosis than
their HPV-negative counterparts but several studies have suggested that among HPV …

Integrative genomic analysis reveals low T-cell infiltration as the primary feature of tobacco use in HPV-positive oropharyngeal cancer

BM Wahle, P Zolkind, RJ Ramirez, ZL Skidmore… - Iscience, 2022 - cell.com
Although tobacco use is an independent adverse prognostic feature in HPV (+)
oropharyngeal squamous cell carcinoma (OPSCC), the biologic features associated with …

Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus–positive oropharyngeal squamous cell carcinoma

S Haft, S Ren, G Xu, A Mark, K Fisch, TW Guo, Z Khan… - Cancer, 2019 - Wiley Online Library
Background Human papillomavirus (HPV)–associated oropharyngeal cancer is a disease
clinically and biologically distinct from smoking‐related head and neck squamous cell …

Tobacco exposure as a major modifier of oncologic outcomes in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma

H Elhalawani, ASR Mohamed, B Elgohari, TA Lin… - BMC cancer, 2020 - Springer
Background The incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the US
is rapidly increasing, driven largely by the epidemic of human papillomavirus (HPV) …

How does smoking change the clinicopathological characteristics of human Papillomavirus-positive oropharyngeal squamous cell carcinoma? One medical center …

C Liu, G Talmor, GMI Low, TV Wang… - … Insights: Ear, Nose …, 2018 - journals.sagepub.com
Introduction: Human papillomavirus (HPV)-positive and HPV-negative oropharyngeal
squamous cell carcinomas (OPSCCs) are 2 distinct cancers, with HPV-positivity conferring a …

Genetic alterations in human papillomavirus-associated oropharyngeal squamous cell carcinoma of patients with treatment failure

H Reder, S Wagner, U Gamerdinger, S Sandmann… - Oral Oncology, 2019 - Elsevier
Objectives Despite improved survival rates of patients with HPV-associated OPSCC, a
subset has distant metastasis or develops local recurrence during follow-up. To investigate …

Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma

M Urashima, T Hama, T Suda, Y Suzuki, M Ikegami… - PloS one, 2013 - journals.plos.org
Background Tobacco and alcohol consumption are risk factors for head and neck squamous
cell carcinoma (HNSCC). Recently, whole-exome sequencing clarified that smoking …