Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria
MVG Lacerda, A Llanos-Cuentas… - … England Journal of …, 2019 - Mass Medical Soc
Abstract Background Treatment of Plasmodium vivax malaria requires the clearing of
asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared …
asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared …
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria
A Llanos-Cuentas, MVG Lacerda, TT Hien… - … England Journal of …, 2019 - Mass Medical Soc
Background Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been
associated with relapse prevention through the clearance of P. vivax parasitemia and …
associated with relapse prevention through the clearance of P. vivax parasitemia and …
Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b …
A Llanos-Cuentas, MV Lacerda, R Rueangweerayut… - The Lancet, 2014 - thelancet.com
Background Clinical effectiveness of previous regimens to treat Plasmodium vivax infection
have been hampered by compliance. We aimed to assess the dose–response, safety, and …
have been hampered by compliance. We aimed to assess the dose–response, safety, and …
Higher-Dose Primaquine to Prevent Relapse of Plasmodium vivax Malaria
NN Chamma-Siqueira, SC Negreiros… - … England Journal of …, 2022 - Mass Medical Soc
Background In most of the Americas, the recommended treatment to prevent relapse of
Plasmodium vivax malaria is primaquine at a total dose of 3.5 mg per kilogram of body …
Plasmodium vivax malaria is primaquine at a total dose of 3.5 mg per kilogram of body …
Randomized Trial of 3-Dose Regimens of Tafenoquine (WR238605) versus Low-Dose Primaquine for Preventing Plasmodium vivax Malaria Relapse
DS Walsh, P Wilairatana, DB Tang… - Clinical Infectious …, 2004 - academic.oup.com
Background. Tafenoquine is an 8-aminoquinoline developed as a more effective
replacement for primaquine. In a previous dose-ranging study in Thailand, 3 tafenoquine …
replacement for primaquine. In a previous dose-ranging study in Thailand, 3 tafenoquine …
Clinical utility of tafenoquine in the prevention of relapse of Plasmodium vivax malaria: a review on the mode of action and emerging trial data
AB Hounkpatin, A Kreidenweiss… - Infection and drug …, 2019 - Taylor & Francis
Tafenoquine is an 8-aminoquinoline with activity against all human life cycle stages of
Plasmodium vivax, including dormant liver stages–so called hypnozoites. Its long half-life …
Plasmodium vivax, including dormant liver stages–so called hypnozoites. Its long half-life …
Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial
WRJ Taylor, K Thriemer, L von Seidlein, P Yuentrakul… - The Lancet, 2019 - thelancet.com
Background Primaquine is the only widely used drug that prevents Plasmodium vivax
malaria relapses, but adherence to the standard 14-day regimen is poor. We aimed to …
malaria relapses, but adherence to the standard 14-day regimen is poor. We aimed to …
[HTML][HTML] High-dose primaquine regimens against relapse of Plasmodium vivax malaria
S Krudsood, N Tangpukdee, P Wilairatana… - The American journal …, 2008 - ncbi.nlm.nih.gov
Plasmodium vivax causes debilitating but usually non-lethal malaria in most of Asia and
South America. Prevention of relapse after otherwise effective therapy for the acute attack …
South America. Prevention of relapse after otherwise effective therapy for the acute attack …
Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria
Background Primaquine is necessary for the radical cure of Plasmodium vivax malaria, but
the optimum duration of treatment and best partner drug are uncertain. A randomized …
the optimum duration of treatment and best partner drug are uncertain. A randomized …
Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Background Primaquine radical cure is used to treat dormant liver-stage parasites and
prevent relapsing Plasmodium vivax malaria but is limited by concerns of haemolysis. We …
prevent relapsing Plasmodium vivax malaria but is limited by concerns of haemolysis. We …