In Vitro Modulation of Renin–Angiotensin System Enzymes by Amaranth (Amaranthus hypochondriacus) Protein-Derived Peptides: Alternative Mechanisms Different …

AV Quiroga, P Aphalo, AE Nardo… - Journal of agricultural …, 2017 - ACS Publications
Among the factors affecting the development of cardiovascular diseases, hypertension is
one of the most important. Research done on amaranth proteins has demonstrated their …

[HTML][HTML] Amaranth as a source of antihypertensive peptides

AE Nardo, S Suárez, AV Quiroga… - Frontiers in Plant Science, 2020 - frontiersin.org
Amaranth is an ancestral crop used by pre-Columbian cultures for 6000 to 8000 years. Its
grains have a relevant chemical composition not only from a nutritional point of view but also …

Purification and hypotensive activity of rapeseed protein-derived renin and angiotensin converting enzyme inhibitory peptides

R He, SA Malomo, A Alashi, AT Girgih, X Ju… - Journal of Functional …, 2013 - Elsevier
Rapeseed protein isolate (RPI) was hydrolyzed with Alcalase followed by reverse-phase
high performance liquid chromatography (RP-HPLC) purification of bioactive peptides. The …

Effect of amaranth proteins on the RAS system. In vitro, in vivo and ex vivo assays

S Suárez, P Aphalo, G Rinaldi, MC Añón, A Quiroga - Food chemistry, 2020 - Elsevier
The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on
spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was …

Renin and angiotensin converting enzyme inhibition with antioxidant properties of African yam bean protein hydrolysate and reverse-phase HPLC-separated peptide …

CF Ajibola, JB Fashakin, TN Fagbemi… - Food Research …, 2013 - Elsevier
Enzymatic hydrolysate of African yam bean seed proteins was prepared by treatment with
alcalase. The African yam bean seed protein hydrolysate (APH) was further separated into …

In vitro renin–angiotensin system inhibition and in vivo antihypertensive activity of peptide fractions from lima bean (Phaseolus lunatus L.)

NA Ciau‐Solís, JJ Acevedo‐Fernández… - Journal of the …, 2018 - Wiley Online Library
BACKGROUND The renin–angiotensin system is key in the physiopathology of arterial
hypertension because it converts angiotensin I, via angiotensin I‐converting enzyme (ACE) …

Amaranth seed protein hydrolysates have in vivo and in vitro antihypertensive activity

M Fritz, B Vecchi, G Rinaldi, MC Añón - Food Chemistry, 2011 - Elsevier
The objective of this work was to study the hydrolytic release of encrypted peptides with
antihypertensive activity from storage proteins of Amaranthus mantegazzianus, as …

Characterization and ACE‐inhibitory activity of amaranth proteins

A Tiengo, M Faria, FM Netto - Journal of Food Science, 2009 - Wiley Online Library
Amaranth seeds have been considered as an excellent alternative or complementary source
of food protein due to their balanced amino acid composition. However, their potential as a …

Isolation and Characterization of Bioactive Pro-Peptides with in Vitro Renin Inhibitory Activities from the Macroalga Palmaria palmata

C Fitzgerald, L Mora-Soler, E Gallagher… - Journal of agricultural …, 2012 - ACS Publications
Renin is the initial rate limiting step in the renin angiotensinogen system (RAS). To combat
hypertension, various stages of the RAS can be positively affected. The aim of this study was …

Structure and function of plant protein-derived antihypertensive peptides

RE Aluko - Current Opinion in Food Science, 2015 - Elsevier
Highlights•Whole protein isolates or specific protein fractions can be used for enzyme
hydrolysis.•Low molecular weight plant peptides (< 3 kDa) are better antihypertensive …