Starting highly active antiretroviral therapy: why, when and response to HAART

A Mocroft, JD Lundgren - Journal of Antimicrobial …, 2004 - academic.oup.com
Highly active antiretroviral therapy (HAART) has dramatically improved the prognosis of
patients with HIV, although it remains unclear as to the best time to start treatment to reduce …

Antiretroviral therapy: The “when to start” debates

CJ Cohen, BA Boyle - Clinical Infectious Diseases, 2004 - academic.oup.com
With the recent approval of several new antiretrovirals and with new research regarding the
efficacy and safety of HAART comes a necessary revisiting of the timing of initiation of …

Highly active antiretroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus type 1

RW Shafer, DA Vuitton - Biomedicine & pharmacotherapy, 1999 - Elsevier
Highly active antiretroviral therapy (HAART) refers to a broad category of treatment regimens
usually comprised of three or more antiretroviral drugs that, in previously untreated HIV-1 …

Achieving a cure for HIV infection: do we have reasons to be optimistic?

V Le Douce, A Janossy, H Hallay, S Ali… - Journal of …, 2012 - academic.oup.com
The introduction of highly active antiretroviral therapy (HAART) in 1996 has transformed a
lethal disease to a chronic pathology with a dramatic decrease in mortality and morbidity of …

Early Versus Delayed Antiretroviral Therapy in Patients with HIV Infectionat: A Review of the Current Guidelines from an Immunological Perspective

AR Thorner, ES Rosenberg - Drugs, 2003 - Springer
The development and implementation of highly active antiretroviral therapy (HAART) for the
treatment of the human immunodeficiency virus has revolutionised the care of patients with …

Early modification of initial HAART regimen associated with poor clinical outcome in HIV patients

WB Park, PG Choe, SH Kim, JH Jo… - AIDS research and …, 2007 - liebertpub.com
Although the importance of the initial regimen in highly active antiretroviral therapy (HAART)
has been emphasized, the effect on clinical outcome of early modification of the initial …

Clinical outcome and predictive factors of failure of highly active antiretroviral therapy in antiretroviral-experienced patients in advanced stages of HIV-1 infection

AA Monforte, L Testa, F Adorni, E Chiesa, T Bini… - Aids, 1998 - journals.lww.com
Objective: To verify the effectiveness of highly active antiretroviral therapy (HAART) and to
identify any factors predictive of clinical outcome in a clinical setting. Design: Observational …

When to Begin Highly Active Antiretroviral Therapy? Evidence Supporting Initiation of Therapy at CD4+ Lymphocyte Counts <350 cells/µL

JE Kaplan, DL Hanson, DL Cohn… - Clinical infectious …, 2003 - academic.oup.com
We assessed the risk of acquired immunodeficiency syndrome (AIDS)-related opportunistic
illness or death among persons first prescribed highly active antiretroviral therapy (HAART) …

Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study

B Ledergerber, M Egger, M Opravil, A Telenti… - The Lancet, 1999 - thelancet.com
Background The efficacy of highly active antiretroviral therapy (HAART) in suppression of
HIV-1 is well documented. We investigated virological and clinical outcomes of HAART in …

Is antiretroviral treatment of primary HIV infection clinically justified on the basis of current evidence?

DE Smith, BD Walker, DA Cooper, ES Rosenberg… - Aids, 2004 - journals.lww.com
When antiretroviral therapy first became available, it was hypothesized that the modest
clinical benefits seen in patients with advanced disease [1] would be more pronounced in …