Connective tissue growth factor–specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis
N Dornhofer, S Spong, K Bennewith, A Salim, S Klaus… - Cancer research, 2006 - AACR
Pancreatic cancer is highly aggressive and refractory to most existing therapies. Past studies
have shown that connective tissue growth factor (CTGF) expression is elevated in human …
have shown that connective tissue growth factor (CTGF) expression is elevated in human …
Connective tissue growth factor–specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer
T Aikawa, J Gunn, SM Spong, SJ Klaus, M Korc - Molecular cancer …, 2006 - AACR
Connective tissue growth factor (CTGF) plays an important role in fibrosis by modulating cell
migration and cell growth but may also modify tumor growth and metastasis. Because CTGF …
migration and cell growth but may also modify tumor growth and metastasis. Because CTGF …
The role of tumor cell–derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth
KL Bennewith, X Huang, CM Ham, EE Graves, JT Erler… - Cancer research, 2009 - AACR
Pancreatic cancer is highly aggressive and refractory to existing therapies. Connective
tissue growth factor (CTGF/CCN2) is a fibrosis-related gene that is thought to play a role in …
tissue growth factor (CTGF/CCN2) is a fibrosis-related gene that is thought to play a role in …
Expression of connective tissue growth factor in pancreatic cancer cell lines
S Kwon, X Munroe, SC Crawley… - International …, 2007 - spandidos-publications.com
Connective tissue growth factor (CTGF/CCN2) is thought to play a role in normal wound
repair and bone remodeling, but also promotes fibrosis in several disease processes …
repair and bone remodeling, but also promotes fibrosis in several disease processes …
Connective tissue growth factor inhibits gastric cancer peritoneal metastasis by blocking integrin α3β1-dependent adhesion
Background Connective tissue growth factor (CTGF) plays important roles in normal and
pathological conditions. The aim of this study was to investigate the role of CTGF in …
pathological conditions. The aim of this study was to investigate the role of CTGF in …
Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
C Wenger, V Ellenrieder, B Alber, U Lacher, A Menke… - Oncogene, 1999 - nature.com
CTGF is an immediate early growth responsive gene that has been shown to be a
downstream mediator of TGFβ actions in fibroblasts and vascular endothelial cells. In the …
downstream mediator of TGFβ actions in fibroblasts and vascular endothelial cells. In the …
Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)
A Charrier, DR Brigstock - Cytokine & growth factor reviews, 2013 - Elsevier
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich matricellular secreted
protein that regulates diverse cell functions including adhesion, migration, proliferation …
protein that regulates diverse cell functions including adhesion, migration, proliferation …
Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal dissemination
CG Jiang, L Lv, FR Liu, ZN Wang, FN Liu, YS Li… - Molecular cancer, 2011 - Springer
Background Connective tissue growth factor (CTGF) has been shown to be implicated in
tumor development and progression. However, the role of CTGF in gastric cancer remains …
tumor development and progression. However, the role of CTGF in gastric cancer remains …
Expression of connective tissue growth factor in cartilaginous tumors
T Shakunaga, T Ozaki, N Ohara… - … Journal of the …, 2000 - Wiley Online Library
BACKGROUND Connective tissue growth factor (CTGF) predominantly is expressed in
hypertrophic chondrocytes and its specific receptors are demonstrated on chondrocytic cells …
hypertrophic chondrocytes and its specific receptors are demonstrated on chondrocytic cells …
Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer
Background & Aims: Connective tissue growth factor (CTGF) has been shown to be
implicated in tumor development and progression. The aim of this study was to investigate …
implicated in tumor development and progression. The aim of this study was to investigate …