Adult male mice were stereotaxically implanted with permanent indwelling guide cannulae
for bilateral injections into the nucleus accumbens (ACB). The effects on spontaneous …

The effects on locomotor activity (LA) of selective agonists for adenosine receptor subtypes
were examined in mice following bilateral injections into the nucleus accumbens (ACB). The …

Adenosine, by acting on adenosine A1 and A2A receptors, exerts opposite modulatory roles
on striatal extracellular levels of glutamate and dopamine, with activation of A1 inhibiting …

Low to moderate doses of amphetamine produce locomotion which is dependent on release
of dopamine in the anteromedial striatum and nucleus accumbens. The effects of selective …

The cellular distribution of adenosine A2A receptor messenger RNA in the central nervous
system was investigated using in situ hybridization with ribonucleotide probes. A specific …

There is considerable evidence of interactions between adenosine A2A receptors and
dopamine D2 receptors in striatal areas, and antagonists of the A2A receptor have been …

In this study, we have used the selective A2A adenosine receptor antagonist KW6002 to
investigate the function of A2A receptors in the Lister hooded rat nucleus accumbens in vitro …

Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich
regions in the central nervous system and mediate inhibition of locomotor activity, we have …

Locomotor activity and sensorimotor gating (measured as prepulse inhibition of startle) are
regulated by mesoaccumbal dopamine. Recent evidence indicated antagonistic interactions …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …