Abstract During the last decades it turned out that the NO/cGMP signaling cascade is one of
the most prominent regulators of a variety of physiological and pathophysiological …

Introduction: The effectiveness of phosphodiesterase type 5 inhibitors (PDE5i) in treating
erectile dysfunction (ED) creates a new field of both medical practice and pharmaceutical …

Purpose: The effects of sildenafil, a highly selective inhibitor of cyclic guanosine
monophosphate-specific phosphodiesterase type 5, on erectile function in the anesthetized …

Prior to the 1970s, erectile dysfunction commanded little clinical interest. Physicians rarely
questioned patients about sexual function, and patients rarely discussed sexual concerns …

Under normal physiological conditions, following sexual stimulation, release of nitric oxide
(NO) from penile non-adrenergic, non-cholinergic nerves and the endothelium activates …

Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents,
both autonomic and somatic, and supraspinal influences from visual, olfactory, and …

Since the early 1980s, research on the mechanisms of penile erection has done much to
clarify erectile physiology and pathophysiology. More recent studies have identified the …

Objectives. To perform a comparative evaluation and follow-up of patients with erectile
dysfunction (ED) who were treated with intracavernous injection of vasoactive drugs, starting …

DRAMATIC ADVANCES IN THE MANAGEMENT of erectile dysfunction have occurred over
the past decade. Oral therapy with vasoactive agents has emerged as first-line treatment …

Erectile dysfunction (ED) occurs in varying degrees in an estimated 20 to 30 million
American men and is associated with adverse effects on quality of life; particularly personal …