Objective: To demonstrate the feasibility of using focused ultrasound to enhance delivery of
PD-1 inhibitors in glioma rats and determine if such an approach increases treatment …

Purpose: The blood–brain barrier (BBB) inhibits adequate dosing/penetration of therapeutic
agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe …

METHODS: We utilized LIPU/MB to deliver doxorubicin and anti-PD-1 blocking antibodies to
murine models and evaluated drug concentrations in the brain. Flow cytometry evaluated …

Diffuse midline glioma with H3K27 mutation is a fatal central nervous system tumor, most
commonly arising in the brainstem. Despite a multitude of clinical trials, prognosis remains …

Purpose/Objective (s) Diffuse midline glioma with H3K27 mutation is a fatal pediatric brain
tumor, most commonly arising in the brainstem. This tumor remains universally fatal, despite …

Glioblastoma multiforme (GBM) diffusely infiltrates normal brain tissue. The presence of the
blood‐brain barrier (BBB) poses difficulties for targeted delivery of currently available …

Abstract Background Interleukin-12 (IL-12) has long been considered to be effective in
triggering an anticancer immune response, however, the dosage has been limited by …

Purpose Glioblastoma (GBM) is a devastating disease. With the current treatment of surgery
followed by chemoradiation, outcomes remain poor, with median survival of only 15 months …

The presence of blood‐brain barrier (BBB) greatly limits the availability of drugs and their
efficacy against glioma. Focused ultrasound (FUS) can induce transient and local BBB …

Drug delivery in diffuse intrinsic pontine glioma is significantly limited by the blood-brain
barrier (BBB). Focused ultrasound (FUS), when combined with the administration of …