Aim: Our objective was to investigate the effects and tolerability of fixed‐dose combination
therapy on blood pressure and LDL in adults without elevated blood pressure or lipid levels …

Abstract Purpose of Review Polypill and its role in cardiovascular disease (CVD) prevention
has been extensively discussed and debated since the inception of the concept in 2003 …

Antihypertensive, lipid lowering, antidiabetic and antiplatelet treatments all substantially
reduce the risk of cardiovascular morbid and fatal events. In real life, however, effective …

Introduction This meta-analysis was performed to assess the efficacy of fixed-dose
combination (polypill) in reducing the risk of mortality and cardiovascular events. Methods …

Background There has been widespread interest in the potential of combination
cardiovascular medications containing aspirin and agents to lower blood pressure and …

Polypill is a fixed‐dose combination of medications with proven benefits for the prevention of
cardiovascular disease (CVD). Its role in CVD prevention has been extensively debated …

Background The feasibility of conducting a large-scale Polypill clinical trial in developing
countries remains unclear. More information is needed regarding the efficacy in reducing the …

Background The cardiovascular disease pandemic has promoted the cardiovascular polypill
as one of the most scalable public health strategies to improve cardiovascular risk by …

Background To assess the blood pressure and lipid-lowering efficacy and tolerability of
'polypills' used in cardiovascular disease prevention trials. Methodology/Principal Findings …

The concept of a fixed-dose combination pill--or'polypill'--for cardiovascular disease
prevention was first proposed by Wald and Law in 2003. Using data from published trials …