Revisiting human natural killer cell subset function revealed cytolytic CD56dimCD16+ NK cells as rapid producers of abundant IFN-γ on activation
A De Maria, F Bozzano, C Cantoni… - Proceedings of the …, 2011 - National Acad Sciences
The two major functions of human natural killer (NK) cells are conventionally associated with
distinct cell subsets. Thus, cytolytic activity is mostly confined to the CD56dimCD16+ subset …
distinct cell subsets. Thus, cytolytic activity is mostly confined to the CD56dimCD16+ subset …
CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells
K Juelke, M Killig, M Luetke-Eversloh… - Blood, The Journal …, 2010 - ashpublications.org
Human natural killer (NK) cells comprise 2 main subsets, CD56bright and CD56dim cells,
that differ in function, phenotype, and tissue localization. To further dissect the heterogeneity …
that differ in function, phenotype, and tissue localization. To further dissect the heterogeneity …
The biology of human natural killer-cell subsets
MA Cooper, TA Fehniger, MA Caligiuri - Trends in immunology, 2001 - cell.com
Human natural killer (NK) cells comprise≈ 15% of all circulating lymphocytes. Owing to their
early production of cytokines and chemokines, and ability to lyse target cells without prior …
early production of cytokines and chemokines, and ability to lyse target cells without prior …
Interleukin‐1β costimulates interferon‐γ production by human natural killer cells
MA Cooper, TA Fehniger, A Ponnappan… - European journal of …, 2001 - Wiley Online Library
Natural killer (NK) cells are an early source of immunoregulatory cytokines during the innate
immune response to viruses, bacteria, and parasites. NK cells provide requisite IFN‐γ to …
immune response to viruses, bacteria, and parasites. NK cells provide requisite IFN‐γ to …
Differential responses to interleukin 2 define functionally distinct subsets of human natural killer cells
DM Baume, MJ Robertson, H Levine… - European journal of …, 1992 - Wiley Online Library
Human natural killer (NK) cells can be subdivided into two populations based on the density
of cell surface CD56 antigen. The great majority (∼ 90%) of NK cells express CD56 at low …
of cell surface CD56 antigen. The great majority (∼ 90%) of NK cells express CD56 at low …
Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
To investigate human natural killer (NK)–cell reactivity in vivo we have reconstituted human
immune system components by transplantation of human hematopoietic progenitor cells into …
immune system components by transplantation of human hematopoietic progenitor cells into …
Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells
B Grzywacz, N Kataria, M Sikora, RA Oostendorp… - Blood, 2006 - ashpublications.org
The stages of human natural killer (NK) cell differentiation are not well established. Culturing
CD34+ progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT-3L, and murine …
CD34+ progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT-3L, and murine …
Identification of committed NK cell progenitors in adult murine bone marrow
EE Rosmaraki, I Douagi, C Roth… - European journal of …, 2001 - Wiley Online Library
Natural killer (NK) cells play important roles in innate immunity by lysing tumor and virally
infected cells and by producing cytokines including interferon‐γ. While NK cell progenitors …
infected cells and by producing cytokines including interferon‐γ. While NK cell progenitors …
The small subset of CD56brightCD16– natural killer cells is selectively responsible for both cell proliferation and interferon‐γ production upon interaction with …
The encounter of NK cells with dendritic cells (DC) undergoing maturation may result in the
induction of NK cell proliferation. Whether such proliferation involves most NK cells or just a …
induction of NK cell proliferation. Whether such proliferation involves most NK cells or just a …
Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
MA Cooper, TA Fehniger, SC Turner… - Blood, The Journal …, 2001 - ashpublications.org
During the innate immune response to infection, monocyte-derived cytokines (monokines),
stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important …
stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important …