Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia‐induced vasodilatation

O Frøbert, G Haink, U Simonsen… - The Journal of …, 2006 - Wiley Online Library
We tested whether hypoxia‐induced coronary artery dilatation could be mediated by an
increase in adenosine concentration within the coronary artery wall or by an increase in …

Role of adenosine in mediating the coronary vasodilative response to acute hypoxia

H GEWIRTZ, RAYA OLSSON… - Cardiovascular …, 1987 - academic.oup.com
To test the hypothesis that adenosine is required to mediate the coronary vasodilative
response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and …

Adenosine deaminase attenuates canine coronary vasodilation during systemic hypoxia

GF Merrill, HF Downey… - American Journal of …, 1986 - journals.physiology.org
The hypothesis that adenosine mediates the coronary vasodilatory response to hypoxia was
tested by determining if intracoronary infusion of the adenosine degrading enzyme …

Adrenergic blockade blunts adenosine concentration and coronary vasodilation during hypoxia.

SC Herrmann, EO Feigl - Circulation research, 1992 - Am Heart Assoc
Myocardial hypoxia is thought to be an important stimulus for increasing interstitial
adenosine concentration. The adenosine hypothesis of coronary control was investigated …

Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts

K Kroll, EO Feigl - American Journal of Physiology-Heart …, 1985 - journals.physiology.org
The adenosine hypothesis of local metabolic control of coronary blood flow was tested in the
unstressed heart with adenosine deaminase, which converts adenosine to nonvasoactive …

Adenosine deaminase attenuates canine coronary vasodilatation during regional non-ischaemic myocardial hypoxia

GF Merrill, HF Downey, S Yonekura… - Cardiovascular …, 1988 - academic.oup.com
To test the hypothesis that adenosine contributes to the coronary hyperaemia produced by
regional non-ischaemic myocardial hypoxia coronary blood flow and myocardial oxygen …

Further evidence for the role of adenosine in

JW Phillis, MH O'Regan, D Song - General Pharmacology: The Vascular …, 1999 - Elsevier
Experiments were performed on isolated, nonworking rat hearts perfused at constant
pressure according to the Langendorff technique to evaluate the role of adenosine in …

Difference in the time course between increases in coronary flow and in effluent adenosine concentration during anoxia in the perfused rat heart

T ISHIBASHI, K ICHIHARA, Y ABIKO - Japanese circulation journal, 1985 - jstage.jst.go.jp
抄録 The isolated rat heart was perfused by Langendorff's technique with either an
oxygenated (95% O 2 and 5% CO 2) or an anoxic (95% N 2 and 5% CO 2) solution. Anoxia …

The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis

JW Phillis, D Song, MH O'Regan - European journal of pharmacology, 1998 - Elsevier
The role of adenosine in rat coronary flow regulation during acidosis was evaluated in
isolated, perfused, Langendorff rat heart preparations exposed to brief periods of …

Adenosine receptor blockade enhances isoproterenol-induced increases in cardiac interstitial adenosine

LJ Heller, WP Dole, DE Mohrman - Journal of molecular and cellular …, 1991 - Elsevier
The failure of adenosine receptor antagonists to consistently attenuate metabolic coronary
vasodilation suggests that adenosine is not a primary regulator of functional hyperemia. An …