Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo

A Akhmedov, I Rozenberg, F Paneni… - European heart …, 2014 - academic.oup.com
Aims Lectin-like oxLDL receptor-1 (LOX-1) mediates the uptake of oxidized low-density
lipoprotein (oxLDL) in endothelial cells and macrophages. However, the different …

Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance

X Chen, G Du - Chinese medical journal, 2007 - journals.lww.com
Lectin-like oxidized low-density lipoprotein receptor-1: pro... : Chinese Medical Journal
Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and …

LOX-1 and atherosclerosis: proof of concept in LOX-1–knockout mice

H Morawietz - Circulation research, 2007 - Am Heart Assoc
An increased plasma level of low-density lipoprotein (LDL) is a well-known risk factor for
endothelial dysfunction and atherosclerosis. 1 The proatherosclerotic potential of LDL may …

Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation

M Honjo, K Nakamura, K Yamashiro… - Proceedings of the …, 2003 - National Acad Sciences
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major endothelial
receptor for oxidized low-density lipoprotein, and is assumed to play a proatherogenic role …

Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E–null mice

K Inoue, Y Arai, H Kurihara, T Kita… - Circulation research, 2005 - Am Heart Assoc
Endothelial dysfunction induced by oxidized low-density lipoprotein (OxLDL) has been
implicated in the pathogenesis of atherosclerosis and vasculopathy. Increased expression of …

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

S Xu, S Ogura, J Chen, PJ Little, J Moss… - Cellular and Molecular Life …, 2013 - Springer
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …

Current concepts of the role of oxidized LDL receptors in atherosclerosis

T Goyal, S Mitra, M Khaidakov, X Wang… - Current atherosclerosis …, 2012 - Springer
Atherosclerosis is characterized by accumulation of lipids and inflammatory cells in the
arterial wall. Oxidized low-density lipoprotein (ox-LDL) plays important role in the genesis …

Elevated soluble lectin‐like oxidized LDL receptor‐1 (sLOX‐1) levels in obese postmenopausal women

TE Brinkley, N Kume, H Mitsuoka, DA Phares… - …, 2008 - Wiley Online Library
We investigated the association between soluble lectin‐like oxidized low‐density lipoprotein
receptor‐1 (sLOX‐1) levels and obesity in older women. Fifty‐one postmenopausal women …

Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells

O Hofnagel, B Luechtenborg, K Stolle… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—Atherogenesis represents a type of chronic inflammation and involves elements
of the immune response, eg, the expression of proinflammatory cytokines. In advanced …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transcriptional regulation by Oct-1 in human endothelial cells: implications for atherosclerosis

J Chen, Y Liu, H Liu, PL Hermonat… - Biochemical …, 2006 - portlandpress.com
LOX-1, a receptor for ox-LDL (oxidized low-density lipoprotein), has recently been
determined to play a critical role in the progression of atherosclerosis. LOX-1 expression …