Motor control requires precise temporal and spatial encoding across distinct motor centers
that is refined through the repetition of learning. The recruitment of motor regions requires …

The cholinergic basal forebrain projects throughout the neocortex, exerting a critical role in
modulating plasticity associated with normal learning. Cholinergic modulation of cortical …

The contribution of the basal forebrain cholinergic system in mediating plasticity of cortical
sensorimotor representations was examined in the context of normal learning. The effects of …

Basal forebrain cholinergic neurons constitute a major neuromodulatory system implicated
in normal cognition and neurodegenerative dementias. Cholinergic projections densely …

Motor skill learning relies on the plasticity of the primary motor cortex as task acquisition
drives cortical motor network remodeling. Large-scale cortical remodeling of evoked motor …

The interaction of descending neocortical outputs and subcortical premotor circuits is critical
for shaping skilled movements. Two broad classes of motor cortical output projection …

Rodents actively learn new motor skills for survival in reaction to changing environments.
Despite the classic view of the primary motor cortex (M1) as a simple muscle relay region, it …

The acquisition and execution of learned motor sequences are mediated by a distributed
motor network, spanning cortical and subcortical brain areas. The sensorimotor striatum is …

The acquisition and execution of motor skills are mediated by a distributed motor network,
spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog …

Basal forebrain (BF) cholinergic neurons provide the cerebral cortex with acetylcholine.
Despite the long-established involvement of these cells in sensory processing, attention …