Alternative splicing plays a major role in shaping tissue-specific transcriptomes. Among the
broad tissue types present in metazoans, the central nervous system contains some of the …

Alternative splicing is a common mechanism for the generation of multiple isoforms of
proteins. It can function to expand the proteome of an organism and can serve as a way to …

Adjacent alternative 3′ splice sites, those separated by≤ 18 nucleotides, provide a unique
problem in the study of alternative splicing regulation; there is overlap of the cis-elements …

A large fraction of protein-coding genes in metazoans undergo alternative pre-mRNA
splicing in tissue-or cell-type-specific manners. Recent genome-wide approaches have …

Alternative splicing (AS) plays a crucial role in the diversification of gene function and
regulation. Consequently, the systematic identification and characterization of temporally …

Alternative pre-mRNA splicing serves as an elegant mechanism for generating
transcriptomic and proteomic diversity between cell and tissue types. In this chapter, we …

Many alternative splicing events are regulated by pentameric and hexameric intronic
sequences that serve as binding sites for splicing regulatory factors. We hypothesized that …

Normal development requires the right splice variants to be made in the right tissues at the
right time. The core splicing machinery is engaged in all splicing events, but which precise …

Alternative splicing (AS) contributes to increased transcriptome and proteome diversity in
various eukaryotic lineages. Previous studies showed low levels of conservation of …

Alternative splicing generates protein diversity and allows for post-transcriptional gene
regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo …