Evaluation of the medicinal potential of two ruthenium (II) polypyridine complexes as one‐and two‐photon photodynamic therapy photosensitizers

J Hess, H Huang, A Kaiser, V Pierroz… - … A European Journal, 2017 - Wiley Online Library
Abstract Two [Ru (phen) 2dppz] 2+ derivatives (phen= 1, 10‐phenantroline, dppz= dipyrido
[3, 2‐a: 2′, 3′‐c] phenazine) with different functional groups on the dppz ligand [dppz‐7, 8 …

Critical overview of the use of Ru (II) polypyridyl complexes as photosensitizers in one-photon and two-photon photodynamic therapy

F Heinemann, J Karges, G Gasser - Accounts of chemical …, 2017 - ACS Publications
Conspectus Photodynamic Therapy (PDT) is an emerging technique to treat certain types of
cancer, bacterial, fungal, and viral infections, and skin diseases. In past years, different …

Highly charged ruthenium (II) polypyridyl complexes as effective photosensitizer in photodynamic therapy

L Conti, A Bencini, C Ferrante, C Gellini… - … A European Journal, 2019 - Wiley Online Library
A comparative study between two novel, highly water soluble, ruthenium (II) polypyridyl
complexes,[Ru (phen) 2L′] and [Ru (phen) 2Cu (II) L′](L and L‐CuII), containing the …

Increasing the π-expansive ligands in ruthenium (II) polypyridyl complexes: synthesis, characterization, and biological evaluation for photodynamic therapy …

MD Pozza, P Mesdom, A Abdullrahman… - Inorganic …, 2023 - ACS Publications
Lack of selectivity is one of the main issues with currently used chemotherapies, causing
damage not only to altered cells but also to healthy cells. Over the last decades …

Increased lipophilicity of halogenated ruthenium (II) polypyridyl complexes leads to decreased phototoxicity in vitro when used as photosensitizers for photodynamic …

S Roy, E Colombo, R Vinck, C Mari, R Rubbiani… - …, 2020 - Wiley Online Library
In the fight against cancer, photodynamic therapy is generating great interest thanks to its
ability to selectively kill cancer cells without harming healthy tissues. In this field, ruthenium …

Recent approaches towards the development of ru (II) polypyridyl complexes for anticancer photodynamic therapy

A Gandosio, K Purkait, G Gasser - Chimia, 2021 - chimia.ch
Photodynamic therapy (PDT) is a remarkable alternative or complementary technique to
chemotherapy, radiotherapy or immunotherapy to treat certain forms of cancer. The …

DNA Intercalating RuII Polypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

C Mari, V Pierroz, R Rubbiani, M Patra… - … A European Journal, 2014 - Wiley Online Library
Six substitutionally inert [RuII (bipy) 2dppz] 2+ derivatives (bipy= 2, 2′‐bipyridine, dppz=
dipyrido [3, 2‐a: 2′, 3′‐c] phenazine) bearing different functional groups on the dppz …

Mechanisms of action of Ru (II) polypyridyl complexes in living cells upon light irradiation

M Jakubaszek, B Goud, S Ferrari… - Chemical …, 2018 - pubs.rsc.org
The unique photophysical properties of Ru (II) polypyridyl complexes make them very
attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date …

Structurally simple osmium (II) polypyridyl complexes as photosensitizers for photodynamic therapy in the near infrared

A Mani, T Feng, A Gandioso, R Vinck… - Angewandte …, 2023 - Wiley Online Library
Five osmium (II) polypyridyl complexes of the general formula [Os (4, 7‐diphenyl‐1, 10‐
phenanthroline) 2L] 2+ were synthesized as photosensitizers for photodynamic therapy by …

A Ru (II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers

J Karges, F Heinemann, F Maschietto, M Patra… - Bioorganic & medicinal …, 2019 - Elsevier
Abstract The use of Photodynamic Therapy (PDT) for the treatment of several kinds of cancer
as well as bacterial, fungal or viral infections has received increasing attention during the …