Immune responses to Aspergillus antigen in IL‐4‐/‐ mice and the effect of eosinophil ablation

VP Kurup, PS Murali, JQ Xia, JN Fink, HY Choi… - Allergy, 1999 - Wiley Online Library
Background: Exposure to Aspergillus fumigatus allergens results in enhanced total serum
IgE and peripheral blood eosinophils in mice. The associated pulmonary inflammation and …

IgE and eosinophil regulation in a murine model of allergic aspergillosis

VP Kurup, H Choi, PS Murali… - Journal of Leucocyte …, 1994 - academic.oup.com
Exposure of BALB/c mice to Aspergillus fumigatus (Af), the antigen responsible for causing
allergic bronchopulmonary aspergillosis in humans, caused elevated levels of serum …

Particulate Aspergillus fumigatus antigens elicit a TH2 response in BALB/c mice

VP Kurup, BWP Seymour, H Choi… - Journal of Allergy and …, 1994 - Elsevier
Background: In order to understand the immunoregulation in allergic aspergillosis, a murine
model was developed by exposing animals to particulate and soluble antigens of …

Immunopathologic responses to Aspergillus antigen in interleukin-4 knockout mice

VP Kurup, J Guo, PS Murali, H Choi, JN Fink - Journal of Laboratory and …, 1997 - Elsevier
Two strains of interleukin-4 (IL-4) gene knockout mice were studied and compared with wild
strains to determine the role of IL-4 in the immunopathogenesis of murine allergic …

Anti‐interleukin (IL)‐4 and ‐IL‐5 antibodies downregulate IgE and eosinophilia in mice exposed to Aspergillus antigens

VP Kurup, PS Murali, J Guo, H Choi, B Banerjee… - Allergy, 1997 - Wiley Online Library
The effect of multiple divided doses compared with single‐dose injections of antibodies to
murine interleukin (IL)‐4 and IL‐5 in their respective downregulation of IgE and eosinophilia …

Role of Particulate Antigens of Aspergillus in Murine Eosinophilia

VP Kurup, H Choi, PS Murali, A Resnick… - International archives of …, 1997 - karger.com
Objective: Allergic bronchopulmonary aspergillosis, a disabling hypersensitivity lung
disease, results from inhalation of Aspergillus fumigatus antigens present in contaminated …

Aspergillus fumigatus antigen induced eosinophilia in mice is abrogated by anti-IL-5 antibody

PS Murali, A Kumar, H Choi, NK Bansal… - Journal of leukocyte …, 1993 - academic.oup.com
A murine model of allergic bronchopulmonary aspergillosis (ABPA), developed by exposure
to Aspergillus fumigatus antigens, demonstrated eosinophilia of peripheral blood (PB), bone …

Aspergillus fumigatusAntigen Exposure Results in Pulmonary Airway Resistance in Wild-Type but Not in IL-4 Knockout Mice

VP Kurup, JQ Xia, DA Rickaby, CA Dawson, H Choi… - Clinical …, 1999 - Elsevier
Inhalation ofAspergillus fumigatus, a ubiquitous fungus, results in the development of
allergic bronchopulmonary aspergillosis, a disabling allergic lung disease. For better patient …

Hyperimmune serum modulates allergic response to spores in a murine model of allergic aspergillosis

PS Murali, BS Bamrah, H Choi, JN Fink… - Journal of Leucocyte …, 1994 - academic.oup.com
Allergic bronchopulmonary aspergillosis (ABPA) is a disease in atopic asthmatics
characterized by eosinophilia and elevated levels of immunoglobulin E (IgE) and IgG …

IgE down regulation and cytokine induction by Aspergillus antigens in human allergic bronchopulmonary aspergillosis

PS Murali, VP Kurup, NK Bansal, JN Fink… - Journal of Laboratory …, 1998 - Elsevier
Allergic bronchopulmonary aspergillosis (ABPA), occurring primarily in patients with asthma
or cystic fibrosis (CF), is a hypersensitivity reaction to Aspergillus fumigatus (Af), and is …