Despite the development of new treatments, the mortality due to invasive pulmonary
aspergillosis remains above 50%, reaching 95% in certain situations. The battle against …

Invasive pulmonary aspergillosis is a devastating complication of immunosuppression that
usually occurs in neutropenic patients. In this setting, augmentation of the antifungal activity …

Aspergillus fumigatus is an important fungal pathogen of the immunocompromised host.
Innate inflammatory and adaptive T cell responses contribute to defense against this …

Aspergillus fumigatus is the most prevalent airborne fungal pathogen and causes fatal
invasive aspergillosis in immunocompromised patients. Given the essential role of dendritic …

We have used interleukin-10 (IL-10) gene knockout mice (IL-10−/−) to examine the role of
endogenous IL-10 in allergic lung responses to Aspergillus fumigatus Ag. In vitro …

Peritoneal macrophages from Toll-like receptor (TLR) 4-deficient ScCr mice produced less
tumor necrosis factor, interleukin (IL)-1α, and IL-1β than did macrophages of control mice …

Previous research in our laboratory has demonstrated that repeated intranasal exposure to
Aspergillus fumigatus conidia in C57BL/6 mice results in a chronic pulmonary inflammatory …

Aspergillus fumigatus (AF) is often pathogenic in immune-deficient individuals and can
cause life-threatening infections such as invasive aspergillosis. The pulmonary epithelial …

Invasive aspergillosis (IA) is a leading cause of mortality in haematological patients.
Appropriate activation of the innate immune system is crucial for the successful clearance of …

ß2 integrin receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common
beta subunit, and are differentially expressed by leukocytes. ß2 integrins are required for cell …