Inhibition of the transcription factors NF-kappa B and AP-1 underlies loss of cytokine gene expression in rat alveolar macrophages treated with a diffusible product …

WJ Nicholson, J Slight, K Donaldson - American journal of …, 1996 - atsjournals.org
The spores of Aspergillus fumigatus have a survival advantage over other respirable fungal
spores in the lung, leading to a number of lung diseases associated with this fungus. We …

Enhanced pulmonary allergic responses to Aspergillus in CCR2−/− mice

K Blease, B Mehrad, TJ Standiford… - The Journal of …, 2000 - journals.aai.org
Allergic responses to Aspergillus species exacerbate asthma and cystic fibrosis. The natural
defense against live Aspergillus fumigatus spores or conidia depends on the recruitment …

Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO

A De Luca, S Bozza, T Zelante, S Zagarella… - Cellular & molecular …, 2010 - nature.com
Innate responses combine with adaptive immunity to generate the most effective form of anti-
Aspergillus immune resistance. Whereas the pivotal role of dendritic cells in determining the …

Aspergillus fumigatus Induces Immunoglobulin E-Independent Mast Cell Degranulation

M Urb, P Pouliot, FN Gravelat, M Olivier… - Journal of Infectious …, 2009 - academic.oup.com
Abstract Background Pulmonary colonization by Aspergillus fumigatus in chronic lung
disease is associated with progressive decline in lung function even in the absence of …

Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus

S Bozza, R Gaziano, A Spreca, A Bacci… - The Journal of …, 2002 - journals.aai.org
Aspergilli are respiratory pathogens and pulmonary infections are usually acquired through
the inhalation of conidia, able to reach small airways and the alveolar space where the …

Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis

V Balloy, M Huerre, JP Latgé… - Infection and immunity, 2005 - Am Soc Microbiol
Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA). This disease is one of
the most life-threatening opportunistic infections in immunocompromised patients. The type …

Phagocytosis and Intracellular Fate of Aspergillus fumigatus Conidia in Alveolar Macrophages

O Ibrahim-Granet, B Philippe, H Boleti… - Infection and …, 2003 - Am Soc Microbiol
Aspergillus fumigatus is the most prevalent airborne fungal pathogen responsible for fatal
invasive aspergillosis in immunocompromised patients. Upon arrival in the lung alveolus …

Disruption of the phospholipase D gene attenuates the virulence of Aspergillus fumigatus

X Li, M Gao, X Han, S Tao, D Zheng… - Infection and …, 2012 - Am Soc Microbiol
Aspergillus fumigatus is the most prevalent airborne fungal pathogen that induces serious
infections in immunocompromised patients. Phospholipases are key enzymes in pathogenic …

Functional Genomics of Innate Host Defense Molecules in Normal Human Monocytes in Response to Aspergillus fumigatus

KJ Cortez, CA Lyman, S Kottilil, HS Kim… - Infection and …, 2006 - Am Soc Microbiol
Aspergillus fumigatus induces the release of innate immune-related molecules from
phagocytic cells early in the course of infection. Little is known, however, about the complex …

Role of TNF-α in pulmonary host defense in murine invasive aspergillosis

B Mehrad, RM Strieter, TJ Standiford - The Journal of Immunology, 1999 - journals.aai.org
Invasive pulmonary aspergillosis is a common and devastating complication of
immunosuppression, whose incidence has increased dramatically in tandem with the …