A defining characteristic of superantigens is their ability to stimulate T cells based
predominantly on the type of variable segment of the T cell receptor (TCR) beta chain (V …

We have used multiple-amino acid replacement mutagenesis to examine the roles of the
TCR homologues of Ig complementarity-determining regions (CDR) and framework …

The T cell receptor (TCR) V beta-determining region of two bacterial superantigens,
staphylococcal enterotoxin A (SEA) and SEE, has been mapped to the COOH-terminal …

Bacterial toxin superantigens bind to MHC class II molecules and activate a large proportion
of T cells through a direct interaction with the T cell receptor (TCR). The toxin: TCR …

Superantigens are able to stimulate T lymphocyte populations expressing T cell antigen
receptors (TCR) belonging to particular Vβ families. Moreover, the presence of these …

The Staphylococcus aureus enterotoxins are known to be potent T cell activators, stimulating
cell proliferation and lymphokine production. Two additional S. aureus proteins, exfoliating …

We have examined the interaction of the microbial superantigen staphylococcal enterotoxin
A (SEA) with peptides corresponding to overlapping regions of the T-cell antigen receptor …

The exotoxins of certain strains of Staphylococcus aureus strains are able both to stimulate
potent proliferation and induce anergy in T lymphocytes expressing the appropriate T cell Ag …

Several bacterial proteins have been recently identified as superantigens which stimulate
large numbers of T cells expressing particular T-cell receptor (TCR) Vβ elements. This …

The last few years have seen an enormous jump in our knowledge and understanding of T-
cell activation by superantigens. Clearly, a great number of infectious and parasitic …