Steroid hormone biosynthesis is catalyzed by the action of a series of cytochrome P450
enzymes as well as reductases. Defects in steroid hydroxylating P450s are the cause of …

Major advances have been made during the last decade in our understanding of adrenal
steroid hormone biosynthesis. Two key players in these pathways are the human …

Four out of six CYP enzymes involved in steroid biosynthesis are very interesting targets for
the development of new drugs in order to treat a variety of severe illnesses. Herein we report …

Cytochrome P450 enzymes (CYPs) are capable of catalyzing regio-and stereo-specific oxy
functionalization reactions, which otherwise are major challenges in organic chemistry. In …

The biosynthesis of steroid hormones is dependent on P450-catalyzed reactions. In
mammals, cholesterol is the common precursor of all steroid hormones, and its conversion …

CYP11B1 is the key enzyme in cortisol biosynthesis, and its inhibition with selective
compounds is a promising strategy for the treatment of diseases associated with elevated …

The steroid hydroxylation and carbon–carbon bond cleavage activities of cytochrome P450
17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens …

Oxysterols and neurosteroids are important signaling molecules produced by
monooxygenases of the cytochrome P450 family that realize their effect through nuclear …

CYP154C5 from Nocardia farcinica is a P450 monooxygenase able to hydroxylate a range
of steroids with high regio‐and stereoselectivity at the 16α‐position. Using protein …

Cytochrome P450s play critical roles in the metabolism of various bioactive compounds.
One of the crucial functions of cytochrome P450s in Chordata is in the biosynthesis of steroid …