Leveraging high-dimensional molecular datasets can help us develop mechanistic insight
into associations between genetic variants and complex traits. In this study, we integrated …

Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …

Genetic determinants of cognition are poorly characterized, and their relationship to genes
that confer risk for neurodevelopmental disease is unclear. Here we performed a systems …

Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …

Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …

The genetics of Alzheimer disease (AD) to date support an age-dependent dichotomous
model whereby earlier age of disease onset (< 60 years) is explained by 3 fully penetrant …

Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …

Background Mouse models have allowed for the direct interrogation of genetic effects on
molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what …

Recent advances toward the characterization of Alzheimer's disease (AD) have permitted
the identification of a dozen of genetic risk factors, although many more remain …

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly.
The National Institute of Aging-Late Onset Alzheimer's Disease Family Study and the …