Central nervous system B cells have several potential roles in multiple sclerosis (MS):
secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …

A role of B cells in multiple sclerosis (MS) is well established, but there is limited
understanding of their involvement during active disease. Here, we examined cerebrospinal …

In multiple sclerosis (MS), lymphocyte—in particular B cell—transit between the central
nervous system (CNS) and periphery may contribute to the maintenance of active disease …

In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain
barrier (BBB). However, it is unclear whether antigen-experienced B cells are shared …

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …

Over the past two decades B cells have increasingly moved into the spotlight in multiple
sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance …

B cells are not limited to producing protective antibodies; they also perform additional
functions relevant to both health and disease. However, the relative contribution of …

Clinical trial results of peripheral B cell depletion indicate abnormal proinflammatory B cell
properties, and particularly antibody-independent functions, contribute to relapsing MS …