Matrix metalloproteinases (MMPs) are extracellular proteases that have well recognized
roles in cell signaling and remodeling in many tissues. In the brain, their activation and …

Background Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome.
Neuroinflammation is an important pathological process for POCD. However, it is not clear …

Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous
system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a …

Elevated levels of the β-amyloid peptide (Aβ) are thought to contribute to cognitive and
behavioral impairments observed in Alzheimer's disease (AD). Protein phosphatase 2A …

It has been postulated that the development of amyloid plaques in Alzheimer's disease (AD)
may result from an imbalance between the generation and clearance of the amyloid-β …

Expression of matrix metalloproteinases (MMPs), especially MMP9 correlates with blood–
brain barrier (BBB) disruption during many neuroinflammatory diseases. During neurotropic …

The neurovascular unit, which consists of astrocytic end-feet, neurons, pericytes, and
endothelial cells, plays a key role in maintaining brain homeostasis by forming the blood …

The chances to develop Alzheimer's disease (AD) result from a combination of genetic and
non-genetic risk factors, the latter likely being mediated by epigenetic mechanisms. In the …

Cerebral accumulation of β-amyloid peptide (Aβ) is a central event in the pathogenesis of
Alzheimer's disease (AD). Several proteases were shown to hydrolyze Aβ in vitro or in cell …

The extracellular matrix (ECM) is a critical regulator of neural network development and
plasticity. As neuronal circuits develop, the ECM stabilizes synaptic contacts, while its …