Alzheimer Disease (AD) is the most prevalent type of dementia. Pathological changes in the
AD brain include Amyloid β-protein (Aβ) plaques and Neurofibrillary Tangles (NFTs), as well …

It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity,
learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the …

Matrix metalloproteinases (MMPs)‐2,‐3 and‐9 are up‐regulated in several cell types on
exposure to amyloid β peptide (Aβ) and have Aβ‐degrading activity in vitro. The aims of this …

Matrix metalloproteinase-9 (MMP-9) may play a role in the inflammatory glial response
during Alzheimer's disease (AD). Astrocytes can degrade beta-amyloid (Aβ) and …

Background Studies have reported higher plasma matrix metalloproteinase-9 (MMP-9)
levels in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Despite evidence …

Impairments of dendritic trees and spines have been found in many neurodegenerative
diseases, including Alzheimer's disease (AD), in which the deficits of melatonin signal …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is
characterized by a progressive cognitive decline in affected individuals. Current therapeutic …

To understand matrix metalloproteinase-9 (MMP-9) involvement in Alzheimer's disease, we
examined mechanisms mediating increased expression of MMP-9 in the presence of Abeta …

This article focuses on the emerging role of matrix metalloproteinase-12 (MMP-12) in
ischaemic stroke (IS). MMP-12 expression in the brain increases dramatically in animal …

A fundamental regulator of neuronal network development and plasticity is the extracellular
matrix (ECM) of the brain. The ECM provides a scaffold stabilizing synaptic circuits, while the …