Muscular dystrophy is defined as the progressive wasting of skeletal muscles that is caused
by inherited or spontaneous genetic mutations. Next‐generation sequencing has greatly …

The muscular dystrophies comprise a heterogeneous group of genetic disorders that
produce progressive skeletal muscle weakness and wasting. There has been rapid growth …

Genetic modifiers can serve as biomarkers for outcomes in DMD. Modifiers can alter
strength and ambulation in muscular dystrophy, and these same features can be used as …

Patients with Duchenne muscular dystrophy (DMD) show clinically relevant phenotypic
variability, despite sharing the same primary biochemical defect (dystrophin deficiency) …

Abstract Purpose of Review Muscular dystrophies are a heterogeneous group of inherited
muscular disorders characterized by progressive muscle weakness and in many cases …

The genetic understanding of the muscular dystrophies has advanced considerably in the
last two decades. Over 25 different individual genes are now known to produce muscular …

Duchenne muscular dystrophy (DMD) is a life‐limiting, neuromuscular disorder that causes
progressive, severe muscle wasting in boys and young men. Although there is no cure …

Duchenne muscular dystrophy (DMD) is a lethal, X-linked neuromuscular disorder caused
by the absence of dystrophin protein, which is essential for muscle fiber integrity. Loss of …

Neuromuscular diseases, which encompass disorders that affect muscle and its innervation,
are highly heritable. Genetic diagnosis now frequently pinpoints the primary mutation …

Background Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular
childhood disorder that causes progressive muscle weakness and degeneration and results …