Purpose Estimated glomerular filtration rate (eGFR) equations reflect kidney function
imprecisely. We aimed to describe whether iohexol-based GFR or eGFRs predict clearance …

Background: Ceftolozane-tazobactam is a new antibiotic against multidrug-resistant
pathogens such as Pseudomonas aeruginosas. Ceftolozane-tazobactam dosage is still …

Objectives Several population pharmacokinetic models for cefepime in critically ill patients
have been described, which all indicate that variability in renal clearance is the main …

This study aimed to evaluate ceftriaxone pharmacokinetics that affects the achievement of
targets in the treatment of critically ill children (meningitis, pneumonia, urinary tract infection …

Objective Cefepime is commonly used in pediatric intensive care units, where unpredictable
variations in the patients' pharmacokinetic (PK) variables may require drug dose …

Ceftriaxone is used commonly for sepsis, including in children requiring continuous kidney
replacement therapy (CKRT). No reports exist of pharmacokinetic (PK) parameters for …

Cefepime exhibits highly variable pharmacokinetics in critically ill patients. The purpose of
this study was to develop and qualify a population pharmacokinetic model for use in the …

Objectives: Augmented renal clearance (ARC) of primarily renally eliminated antibacterial
agents may result in subtherapeutic antibiotic concentrations and, as a consequence, worse …

Aims Glomerular filtration rate (GFR) is difficult to assess in critically ill children using gold
standard method and alternatives are needed. This study aimed to determine the most …

Ceftolozane-tazobactam, a combination of the novel antipseudomonal cephalosporin
ceftolozane and the well-established extended-spectrum β-lactamase inhibitor tazobactam …