Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury
M Amirbekyan, V Adhikarla, JP Cheng… - Scientific Reports, 2023 - nature.com
Efficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful
delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc …
delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc …
[HTML][HTML] Intranasally administered L-Myc-immortalized human neural stem cells migrate to primary and distal sites of damage after cortical impact and enhance spatial …
M Gutova, JP Cheng, V Adhikarla, L Tsaturyan… - Stem Cells …, 2021 - hindawi.com
As the success of stem cell-based therapies is contingent on efficient cell delivery to
damaged areas, neural stem cells (NSCs) have promising therapeutic potential because …
damaged areas, neural stem cells (NSCs) have promising therapeutic potential because …
Intranasal Administration of Human MSC for Ischemic Brain Injury in the Mouse: In Vitro and In Vivo Neuroregenerative Functions
V Donega, CH Nijboer, L Braccioli… - PLoS …, 2014 - journals.plos.org
Intranasal treatment with C57BL/6 MSCs reduces lesion volume and improves motor and
cognitive behavior in the neonatal hypoxic-ischemic (HI) mouse model. In this study, we …
cognitive behavior in the neonatal hypoxic-ischemic (HI) mouse model. In this study, we …
[HTML][HTML] Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury
V Donega, CH Nijboer, G van Tilborg… - Experimental …, 2014 - Elsevier
Previous work from our group has shown that intranasal MSC-treatment decreases lesion
volume and improves motor and cognitive behavior after hypoxic–ischemic (HI) brain …
volume and improves motor and cognitive behavior after hypoxic–ischemic (HI) brain …
[PDF][PDF] L-MYC expression maintains self-renewal and prolongs multipotency of primary human neural stem cells
Pre-clinical studies indicate that neural stem cells (NSCs) can limit or reverse CNS damage
through direct cell replacement, promotion of regeneration, or delivery of therapeutic agents …
through direct cell replacement, promotion of regeneration, or delivery of therapeutic agents …
[HTML][HTML] Neurotrophy and immunomodulation of induced neural stem cell grafts in a mouse model of closed head injury
M Gao, H Yao, Q Dong, Y Zhang, Y Yang, Y Zhang… - Stem cell …, 2017 - Elsevier
Closed head injury (CHI) usually results in severe and permanent neurological impairments,
which are caused by several intertwined phenomena, such as cerebral edema, blood-brain …
which are caused by several intertwined phenomena, such as cerebral edema, blood-brain …
Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular pathology after experimental traumatic brain injury
AMB Heile, C Wallrapp, PM Klinge, A Samii… - Neuroscience …, 2009 - Elsevier
Purpose:“Naked” human mesenchymal stem cells (MSC) are neuro-protective in
experimental brain injury (TBI). In a controlled cortical impact (CCI) rat model, we …
experimental brain injury (TBI). In a controlled cortical impact (CCI) rat model, we …
Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFκB-mediated increase in interleukin-6 production
PA Walker, MT Harting, F Jimenez… - Stem cells and …, 2010 - liebertpub.com
Mesenchymal stromal cell (MSC) therapy has shown promise for the treatment of traumatic
brain injury (TBI). Although the mechanism (s) by which MSCs offer protection is unclear …
brain injury (TBI). Although the mechanism (s) by which MSCs offer protection is unclear …
[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction
Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
Human neural stem cell transplants to address multiple pathologies associated with traumatic brain injury
H Clervius, M Baig, A Mahavadi… - Neural Regeneration …, 2019 - journals.lww.com
Traumatic brain injury (TBI), an unmet need: TBI is an alteration in brain function caused by
an external force with evidence of brain pathology. It could be from a bump, blow, blast or jolt …
an external force with evidence of brain pathology. It could be from a bump, blow, blast or jolt …