Clues to our evolutionary history lie hidden within DNA sequence data. One of the great
challenges facing population geneticists is to identify and accurately interpret these clues …

There is an increasing interest in detecting genes, or genomic regions, that have been
targeted by natural selection. The interest stems from a basic desire to learn more about …

Several statistical tests based on population genetic theory are used to identify genes that
have recently acquired a beneficial mutation. Here, I describe the extension of these tests to …

In the study of molecular and phenotypic evolution, understanding the relative importance of
random genetic drift and positive selection as the mechanisms for driving divergences …

The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Recently, inter-population comparisons of allele frequencies to detect past selection haven
gained popularity. Data from genome-wide scans are used to detect the number and …

One of the central goals of evolutionary biology is to understand the genetic basis of
adaptive evolution. The availability of nearly complete genome sequences from a variety of …

Population geneticists have long sought to understand the contribution of natural selection
to molecular evolution. A variety of approaches have been proposed that use population …

Teasing apart the effects of selection and demography on genetic polymorphism remains
one of the major challenges in the analysis of population genomic data. The traditional …

A complete understanding of the role of natural selection in driving evolutionary change
requires accurate estimates of the strength of selection acting in the wild. Accordingly …