[HTML][HTML] Synthesis of 16 New Hybrids from Tetrahydropyrans Derivatives and Morita-Baylis-Hillman Adducts: In Vitro Screening against Leishmania donovani
SC de Oliveira Sousa, J da Câmara Rocha… - Molecules, 2017 - mdpi.com
Leishmaniases are a group of neglected tropical diseases (NTDs) caused by protozoan
parasites from> 20 Leishmania species. Visceral leishmaniasis (VL), also known as kala …
parasites from> 20 Leishmania species. Visceral leishmaniasis (VL), also known as kala …
Efficient synthesis of 16 aromatic Morita–Baylis–Hillman adducts: Biological evaluation on Leishmania amazonensis and Leishmania chagasi
CGL Junior, PAC de Assis, FPL Silva, SCO Sousa… - Bioorganic …, 2010 - Elsevier
Sixteen aromatic Morita–Baylis–Hillman adducts (MBHA) 1–16 were efficiently synthesized
in a one step Morita–Baylis–Hillman reaction (MBHR) involving commercial aldehydes with …
in a one step Morita–Baylis–Hillman reaction (MBHR) involving commercial aldehydes with …
Synthesis and activity of novel homodimers of Morita–Baylis–Hillman adducts against Leishmania donovani: A twin drug approach
WAV da Silva, DC Rodrigues, RG de Oliveira… - Bioorganic & medicinal …, 2016 - Elsevier
It is reported here the synthesis of novel Homodimers 12–19 of Morita–Baylis–Hillman
adducts (MBHA) from one-pot Morita–Baylis–Hillman Reaction (MBHR) between aromatic …
adducts (MBHA) from one-pot Morita–Baylis–Hillman Reaction (MBHR) between aromatic …
Synthesis and In Vitro Anti Leishmania amazonensis Biological Screening of Morita-Baylis-Hillman Adducts Prepared from Eugenol, Thymol and Carvacrol.
FJ Seixas Xavier, KA da Franca Rodrigues… - …, 2016 - search.ebscohost.com
Leishmaniasis represents a series of severe neglected tropical diseases caused by
protozoa of the genus Leishmania and is widely distributed around the world. Here, we …
protozoa of the genus Leishmania and is widely distributed around the world. Here, we …
Synthesis, evaluation against Leishmania amazonensis and cytotoxicity assays in macrophages of sixteen new congeners Morita–Baylis–Hillman adducts
FPL Silva, PAC de Assis, CGL Junior… - European journal of …, 2011 - Elsevier
We report the design, synthesis, in vitro evaluation against Leishmania amazonensis (IC50),
cytotoxicity assays in macrophages (CC50), and selectivity index (SICC50/IC50) of sixteen …
cytotoxicity assays in macrophages (CC50), and selectivity index (SICC50/IC50) of sixteen …
Leishmanicidal activity of Morita-Baylis–Hillman adducts
ACS Vieira, M da Silva Santos, AB Leite… - Parasitology …, 2022 - Springer
Leishmaniasis is a neglected disease that affects millions of people, mostly in developing
countries. Although this disease has a high impact on public health, there are few drug …
countries. Although this disease has a high impact on public health, there are few drug …
Improved synthesis of seven aromatic Baylis–Hillman adducts (BHA): evaluation against Artemia salina Leach. and Leishmania chagasi
TP Barbosa, CGL Junior, FPL Silva, HM Lopes… - European Journal of …, 2009 - Elsevier
We described a very efficient procedure to prepare seven aromatic compounds (1–7), a new
class of antileishmanial substances, through Baylis–Hillman reaction (BHR). With one, all …
class of antileishmanial substances, through Baylis–Hillman reaction (BHR). With one, all …
[HTML][HTML] Synthesis and In Vitro Anti Leishmania amazonensis Biological Screening of Morita-Baylis-Hillman Adducts Prepared from Eugenol, Thymol and Carvacrol
FJS Xavier, KAF Rodrigues, RG De Oliveira… - Molecules, 2016 - mdpi.com
Leishmaniasis represents a series of severe neglected tropical diseases caused by
protozoa of the genus Leishmania and is widely distributed around the world. Here, we …
protozoa of the genus Leishmania and is widely distributed around the world. Here, we …
Morita–Baylis–Hillman adducts: Biological activities and potentialities to the discovery of new cheaper drugs
CG Lima–Junior, MLAA Vasconcellos - Bioorganic & medicinal chemistry, 2012 - Elsevier
This review aims to present by the first time the Morita–Baylis–Hillman adducts (MBHA) as a
new class of bioactive compounds and highlight its potentialities to the discovery of new …
new class of bioactive compounds and highlight its potentialities to the discovery of new …
[HTML][HTML] Design, synthesis and antileishmanial in vitro activity of new series of chalcones-like compounds: A molecular hybridization approach
TP Barbosa, SCO Sousa, FM Amorim… - Bioorganic & medicinal …, 2011 - Elsevier
The chalcone-like series 1a–1g was efficiently synthesized from Morita–Baylis–Hillman
reaction (52–74% yields). Compounds 1a–1g were designed by molecular hybridization …
reaction (52–74% yields). Compounds 1a–1g were designed by molecular hybridization …