Hydroxymethylcytosine (5hmC) is an oxidative product of 5-methylcytosine (5mC), catalyzed
by the ten eleven translocation (TET) family of enzymes. Although 5hmC was discovered …

Several research groups have recently reported on markedly reduced levels of 5-
hydroxymethylcytosine (5hmC) in human breast, liver, lung, pancreatic, colon, prostate …

Recent studies reported the presence of 5-hydroxymethylcytosine (5 hmC) as an additional
modification in mammalian genomic DNA. To date, 5 hmC has been detected only in mouse …

ABSTRACT DNA cytosine-5 methylation is a well-studied epigenetic pathway implicated in
gene expression control and disease pathogenesis. Different technologies have been …

The discovery of the Ten‐Eleven‐Translocation (TET) oxygenases that catalyze the
hydroxylation of 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) has triggered …

Background Replication-independent active/enzymatic demethylation may be an important
process in the functioning of somatic cells. The most plausible mechanisms of active 5 …

Abstract In contrast to 5-methylcytosine (5-mC), which has been studied extensively,,, little is
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …

5-Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and
genome stability, and aberrant DNA methylation contributes to aging and cancer. Active …

5-Methylcytosine (5-mC), an important epigenetic modification involved in development, can
be converted enzymatically to 5-hydroxymethylcytosine (5-hmC). 5-hmC is considered an …

A complete understanding of the potential function of 5-hydroxymethylcytosine (5-hmC), a
DNA cytosine modification in mammalian cells, requires an accurate single-base resolution …