Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors
that induce inflammation are not well understood. We previously identified a cell …

Plasma cell‐free DNA (cf‐DNA) has recently emerged as a potential biomarker of aging,
reflecting systemic inflammation, and cell death. In addition, it has been suggested that cf …

How DNA damage leads to chronic inflammation and tissue degeneration with aging
remains to be fully resolved. Here, we show that DNA damage leads to cellular senescence …

Adult stem cells ensure tissue homeostasis and regeneration after injury. Due to their
longevity and functional requirements, throughout their life stem cells are subject to a …

Besides constituting a first layer of defense against microbial challenges, the detection of
cytosolic DNA is fundamental for mammalian organisms to control malignant transformation …

Inflammation benefits the host by promoting the elimination of invading pathogens and
clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and …

Endogenous DNA is primarily found intracellularly in nuclei and mitochondria. However,
extracellular, cell-free (cf) DNA, has been observed in several pathological conditions …

The innate immune system provides early defense against infections and also plays a key
role in monitoring alterations of homeostasis in the body. DNA is highly immunostimulatory …

Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and
silencing,,. However, we recently discovered the presence of cytoplasmic chromatin …