Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the
molecular mechanisms of which are only partially elucidated. In this study, we describe a …

Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging
and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a …

Activation of persistent DNA damage response (DDR) signaling is associated with the
induction of a permanent proliferative arrest known as cellular senescence, a phenomenon …

Inflammatory cytokines promote the activation of coagulation through the induction of tissue
factor, downregulation of thrombomodulin and upregulation of plasminogen activator …

The interaction of innate immune cells with pathogens leads to changes in gene expression
that elicit our body's first line of defense against infection. Although signaling pathways and …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a
major mediator of inflammation following stimulation with> 45 bp double-stranded DNA …

Monocytes and macrophages are essential components of the innate immune system.
Herein, we report that intron retention (IR) plays an important role in the development and …

Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …

Deficiencies in DNA-degrading nucleases lead to accumulation of self DNA and induction of
autoimmunity in mice and in monogenic and polygenic human diseases. However, the …