Emerging role of phospholipids and lysophospholipids for improving brain docosahexaenoic acid as potential preventive and therapeutic strategies for neurological …

M Hachem, H Nacir - International Journal of Molecular Sciences, 2022 - mdpi.com
Docosahexaenoic acid (DHA, 22: 6n-3) is an omega-3 polyunsaturated fatty acid (PUFA)
essential for neural development, learning, and vision. Although DHA can be provided to …

Targeting the brain with a neuroprotective omega-3 fatty acid to enhance neurogenesis in hypoxic condition in culture

A Lo Van, N Sakayori, M Hachem, M Belkouch… - Molecular …, 2019 - Springer
Abstract Docosahexaenoic acid (DHA, 22: 6n-3) is an essential omega-3 polyunsaturated
fatty acid (PUFA) that is required for proper brain development and cerebral functions. While …

Structured form of DHA prevents neurodegenerative disorders: A better insight into the pathophysiology and the mechanism of DHA transport to the brain

J Balakrishnan, S Kannan, A Govindasamy - Nutrition Research, 2021 - Elsevier
Docosahexaenoic acid (DHA) is one of the most important fatty acids that plays a critical role
in maintaining proper brain function and cognitive development. Deficiency of DHA leads to …

Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases

AL Van, N Sakayori, M Hachem, M Belkouch, M Picq… - Biochimie, 2016 - Elsevier
Abstract Docosahexaenoic acid (DHA; 22: 6 ω-3) is highly enriched in the brain and is
required for proper brain development and function. Its deficiency has been shown to be …

Brain targeting with docosahexaenoic acid as a prospective therapy for neurodegenerative diseases and its passage across blood brain barrier

M Hachem, M Belkouch, AL Van, M Picq… - Biochimie, 2020 - Elsevier
Abstract Docosahexaenoic acid (DHA, 22: 6n-3) is the main omega-3 polyunsaturated fatty
acid in brain tissues necessary for common brain growth and function. DHA can be provided …

Essential role of docosahexaenoic acid towards development of a smarter brain

K Gharami, M Das, S Das - Neurochemistry international, 2015 - Elsevier
Evolution of the high order brain function in humans can be attributed to intake of poly
unsaturated fatty acids (PUFAs) of which the ω-3 fatty acid, docosahexaenoic acid (DHA) …

Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid

HY Kim, M Akbar, YS Kim - … Leukotrienes and Essential Fatty Acids (PLEFA …, 2010 - Elsevier
Enrichment of polyunsaturated fatty acids, particularly docosahexaenoic acid (DHA, 22: 6n−
3), in the brain is known to be critical for optimal brain development and function …

New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain

R Gomes, I Mendes, MP Duarte, NM Bandarra… - Marine Drugs, 2024 - mdpi.com
Low levels of docosahexaenoic acid (DHA) in the brain have been related to neurological
disorders, like Alzheimer's disease (AD). After ingestion, dietary DHA must cross the blood …

Esterification of Docosahexaenoic Acid Enhances Its Transport to the Brain and Its Potential Therapeutic Use in Brain Diseases

A Lo Van, N Bernoud-Hubac, M Lagarde - Nutrients, 2022 - mdpi.com
Docosahexaenoic acid-containing lysophosphatidylcholine (DHA-LysoPC) is presented as
the main transporter of DHA from blood plasma to the brain. This is related to the major …

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases

GY Sun, A Simonyi, KL Fritsche, DY Chuang… - … and Essential Fatty …, 2018 - Elsevier
Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in
phospholipids in the brain and retina, is known to play multi-functional roles in brain health …