Objective To study differences in cardiovascular risk factors and diseases between patients
with and without genetic variants in the leptin-melanocortin pathway. Methods A cross …

Background Polymorphisms in genes encoding proteins of the leptin-melanocortin pathway
have been associated with obesity. The involvement of these polymorphisms with changes …

Polymorphisms of leptin-melanocortin system genes associated with obesity in an adult
population from Barranquilla SciELO - Scientific Electronic Library Online vol.40 issue2 …

Background: Rare mutations in the leptin (LEP) gene cause severe obesity. Common
polymorphisms of LEP have been associated with obesity, but their association with …

Background: The genetic contribution to obesity is substantial and may underpin the altered
pathophysiology. One such pathway involves melanocortin signaling in the hypothalamus …

Background To examine the association of increased plasma leptin concentration with
prevalent stroke and coronary heart disease (CHD) and to examine the genetic contributions …

In humans, production of the adipocyte-derived peptide leptin has been linked to adiposity,
insulin, and insulin sensitivity. We therefore considered that alterations in plasma leptin …

Leptin, an adipose tissue–derived hormone, has been linked to cardiovascular outcomes;
however, data are limited in the United States population, especially women. To assess the …

Objectives Leptin polymorphism (LEP) has been associated with coronary heart disease
(CAD), obesity, and high body mass index (BMI). However, we performed a systematic …

Objective Higher serum leptin levels have been associated with a modestly higher incidence
of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess …