Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides

H Li, N Anuwongcharoen, AA Malik… - International journal of …, 2016 - mdpi.com
Host defense peptides (HDPs) are positively-charged and amphipathic components of the
innate immune system that have demonstrated great potential to become the next …

Cationic host defence peptides: innate immune regulatory peptides as a novel approach for treating infections

N Mookherjee, REW Hancock - Cellular and molecular life sciences, 2007 - Springer
An increase in antibiotic resistance and the emergence of new pathogens has led to an
urgent need for alternative approaches to infection management. Immunomodulatory …

Post-translational modifications of natural antimicrobial peptides and strategies for peptide engineering

G Wang - Current biotechnology, 2012 - ingentaconnect.com
Natural antimicrobial peptides (AMPs) are gene-coded defense molecules discovered in all
the three life domains: Eubacteria, Archaea, and Eukarya. The latter covers protists, fungi …

Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold

B Findlay, GG Zhanel, F Schweizer - Antimicrobial agents and …, 2010 - Am Soc Microbiol
Naturally occurring cationic antimicrobial peptides (AMPs) and their mimics form a diverse
class of antibacterial agents currently validated in preclinical and clinical settings for the …

Combination effects of antimicrobial peptides

G Yu, DY Baeder, RR Regoes… - Antimicrobial agents and …, 2016 - Am Soc Microbiol
Antimicrobial peptides (AMPs) are ancient and conserved across the tree of life. Their
efficacy over evolutionary time has been largely attributed to their mechanisms of killing. Yet …

Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents

N Wiradharma, U Khoe, CAE Hauser, SV Seow… - Biomaterials, 2011 - Elsevier
Antimicrobial peptides (AMPs) secreted by the innate immune system are prevalent as the
effective first-line of defense to overcome recurring microbial invasions. They have been …

Perspectives for clinical use of engineered human host defense antimicrobial peptides

ME Pachón-Ibáñez, Y Smani, J Pachon… - FEMS microbiology …, 2017 - academic.oup.com
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …

Antimicrobial peptides: natural effectors of the innate immune system

K Radek, R Gallo - Seminars in immunopathology, 2007 - Springer
Antimicrobial peptides (AMPs) are an evolutionarily conserved component of the innate
immune system that defend against invading bacteria, viruses, and fungi through membrane …

Antimicrobial peptides: key components of the innate immune system

M Pasupuleti, A Schmidtchen… - Critical reviews in …, 2012 - Taylor & Francis
Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …

A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …