Population-based prospective surveillance of invasive pneumococcal disease was done in
Southern California from 31 March 1992 to 1 April 1995; 814 cases were identified, for an …

Background: On the basis of the success of the early trials in the prevention of invasive
pneumococcal disease in infants and children using a heptavalent conjugate pneumococcal …

Objective. To evaluate the impact of the introduction and routine use of seven valent
pneumococcal conjugate vaccine on the epidemiology of invasive pneumococcal disease …

Background. Invasive pneumococcal disease (IPD) is a burgeoning problem, with rates of
antibiotic-nonsusceptible IPD, in particular, increasing during the past decade. One measure …

METHODS CHP is a 235-bed regional pediatric referral center that provides both primary
and subspecialty pediatric services to∼ 5.5 million residents in eastern Ohio, West Virginia …

Invasive infections caused by Streptococcus pneumoniae continue to be a major cause of
morbidity and mortality worldwide, especially in children under 5 years of age. In the United …

Children younger than age 2 years have the highest rates of invasive pneumococcal
disease and play an important role in its transmission. In the United States, seven …

Background. The rate of invasive pneumococcal disease (IPD) has decreased among both
immunized children and nonimmunized adults since the licensure of a heptavalent …

Objective: To assess the direct and indirect effects of the introduction of routine use of
pneumococcal conjugate vaccine in infants and toddlers at risk for invasive disease caused …

Pneumococcal conjugate vaccine use among young children has led to significant declines
in invasive pneumococcal disease in the United States, but the impact on community …