1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (Pf IspC, Pf
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …

Malaria is a global health threat that requires immediate attention. Malaria is caused by the
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …

Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key
enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium …

Abstract Blocking the 2‐C‐methyl‐d‐erythrithol‐4‐phosphate pathway for isoprenoid
biosynthesis offers new ways to inhibit the growth of Plasmodium spp. Fosmidomycin [(3‐(N …

1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) in the nonmevalonate isoprene
biosynthesis pathway is a target for developing antimalarial drugs. Fosmidomycin, a potent …

Specific inhibition of enzymes of the non-mevalonate pathway is a promising strategy for the
development of novel antiplasmodial drugs. α-Aryl-substituted β-oxa isosteres of …

Malaria, a mosquito-borne disease caused by several parasites of the Plasmodium genus,
remains a huge threat to global public health. There are an estimated 0.5 million malaria …

Fosmidomycin and its homologue FR900098 are inhibitors of 1‐deoxy‐d‐xylulose‐5‐
phosphate reductoisomerase, which is part of the mevalonate‐independent isoprenoid …

Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate
pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized …

The human malaria parasite Plasmodium falciparum is responsible for the deaths of more
than a million people each year. Fosmidomycin has been proven to be efficient in the …