The sesquiterpene synthase 7-epi-α-eudesmol synthase is widespread in streptomycetes.
Several active site residues that were identified by an alignment of their amino acid …

Medermycin is a Streptomyces aromatic C-glycoside antibiotic classified in the
benzoisochromanequinones (BIQs), which presents several interesting biosynthetic …

Heterologous gene expression is one of the main strategies used to access the full
biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural …

Geosmin is a secondary metabolite responsible for earthy tastes and odors in potable water
supplies. Geosmin continues to be a challenge to water utility management regimes and …

The biosynthetic gene cluster of goadsporin, a polypeptide antibiotic containing thiazole and
oxazole rings, was cloned from Streptomyces sp. TP-A0584. The cluster contains a structural …

Streptomyces are Gram-positive bacteria of significant industrial importance due to their
ability to produce a wide range of antibiotics and bioactive secondary metabolites. Recent …

Individual Streptomyces species have the genetic potential to produce a diverse array of
natural products of commercial, medical and veterinary interest. However, these products …

Soil grains harbor an astonishing diversity of Streptomyces strains producing diverse
secondary metabolites. However, it is not understood how this genotypic and chemical …

Streptomyces coelicolor is the genetically best characterized species of a populous genus
belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil …

An important unresolved issue in microbial secondary metabolite production is the
abundance of biosynthetic gene clusters that are not expressed under typical laboratory …