Immune senescence and periodontitis: From mechanism to therapy

J Liu, R Dan, X Zhou, J Xiang, J Wang… - Journal of Leukocyte …, 2022 - academic.oup.com
Periodontitis is one of the most prevalent infectious inflammatory diseases, characterized by
irreversible destruction of the supporting tissues of teeth, which is correlated with a greater …

Age‐related changes in immune function (immune senescence) in caries and periodontal diseases: a systematic review

PM Preshaw, K Henne, JJ Taylor… - Journal of clinical …, 2017 - Wiley Online Library
Aim To systematically review the evidence regarding immune senescence in the
pathogenesis of periodontitis and dental caries. Methods A systematic search of electronic …

Age and periodontal health—immunological view

JL Ebersole, DA Dawson, P Emecen Huja… - Current Oral Health …, 2018 - Springer
Abstract Purpose of the Review Aging clearly impacts a wide array of systems, in particular
the breadth of the immune system leading to immunosenescence, altered immunoactivation …

Aging and its impact on innate immunity and inflammation: implications for periodontitis

G Hajishengallis - Journal of oral biosciences, 2014 - Elsevier
The elderly exhibit increased susceptibility to a number of inflammatory or degenerative
pathologies. Aging is similarly thought to be associated with increased prevalence and …

Periodontal disease as a model to study chronic inflammation in aging

M Bertolini, D Clark - GeroScience, 2023 - Springer
Periodontal disease is a chronic inflammatory condition that results in the destruction of the
teeth supporting tissues, eventually leading to the loss of teeth and reduced quality of life. In …

Aging, inflammation, immunity and periodontal disease

JL Ebersole, CL Graves, OA Gonzalez… - Periodontology …, 2016 - Wiley Online Library
The increased prevalence and severity of periodontal disease have long been associated
with aging, such that this oral condition affects the majority of the adult population over 50 …

[HTML][HTML] Is immunesenescence a contributing factor for periodontal diseases?

M Rajendran, V Priyadharshini… - Journal of Indian Society …, 2013 - journals.lww.com
Current concept in periodontal diseases (PDs) states that it is the host's response toward the
periodontal pathogens which leads to tissue destruction and attachment loss. Hence the role …

[HTML][HTML] Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health

V Villalobos, M Garrido, A Reyes, C Fernández… - Frontiers in …, 2022 - frontiersin.org
Aging is a gradual and progressive deterioration of integrity across multiple organ systems
that negatively affects gingival wound healing. The cellular responses associated with …

Too old to fight? Aging and its toll on innate immunity

G Hajishengallis - Molecular oral microbiology, 2010 - Wiley Online Library
Elderly individuals display increased susceptibility to chronic inflammatory diseases and
microbial infections, such as periodontitis and oral aspiration pneumonia. The resurgent …

[HTML][HTML] Cellular mechanisms of inflammaging and periodontal disease

D Clark, A Radaic, Y Kapila - Frontiers in dental medicine, 2022 - frontiersin.org
Increased age is associated with an increased prevalence of chronic inflammatory diseases
and conditions. The term inflammaging has been used to describe the age-related changes …