Background It is known that the hypothalamic-pituitary-adrenal (HPA) axis is highlighted by
stimulation, such as sepsis, trauma, etc, when corticortropin increases and plasma cortisol …

The use of corticosteroids in septic shock remains controversial. It has been demonstrated
that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not …

Objective To characterise the plasma cortisol profile and adreno-cortial responsiveness
(short Synacthen test) of patients in septic shock. Design Retrospective assessment using …

The role of corticosteroid therapy in the management of septic shock has been debated for
half a century. Results from large, well-designed, randomized clinical trials demonstrate no …

The randomized study conducted by Dr. Bollaert and colleagues [1] apparently contradicts
previous large, randomized, multicenter trials investigating sepsis and early acute …

Septic shock is one of the leading causes of death in intensive care units world-wide.
Scientists have made great improvements in understanding mechanisms of inflammation …

Purpose To investigate if plasma cytokine concentrations predict a beneficial response to
corticosteroid treatment in septic shock patients. Methods A cohort of septic shock patients in …

Published data on adrenocortical function in septic shock have enrolled patients at various
stages of critical illness and predominantly used plasma total cortisol, with minimal …

Objective To compare the total plasma cortisol values obtained from three widely used
immunoassays and a high pressure liquid chromatography (HPLC) technique on samples …

Objective: To develop consensus statements for the diagnosis and management of
corticosteroid insufficiency in critically ill adult patients. Participants: A multidisciplinary …