Anticoagulant heparin has been shown to possess important biological functions that vary
according to its fine structure. Variability within heparin's structure occurs owing to its …

The history of heparin is described from its initial discovery in 1916 to recent developments
in knowledge of its mechanism of action and clinical use. Commercial production started …

Heparin and heparan sulfates are closely related linear anionic polysaccharides, called
glycosaminoglycans, which exhibit a number of important biological and pharmacological …

We investigated the mechanisms of anticoagulant activity mediated by sulfated galactans.
The anticoagulant activity of sulfated polysaccharides is achieved mainly through …

Heparin has been used as a clinical anticoagulant for more than 50 years, making it one of
the most effective pharmacological agents known. Much of heparin's activity can be traced to …

The biological activity of heparan sulphate (HS) and heparin largely depends on internal
oligosaccharide sequences that provide specific binding sites for an extensive range of …

Heparan sulphate (HS) polysaccharides are covalently attached to the core proteins of
various proteoglycans at cell surfaces and in the extracellular matrix. They are composed of …

Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100
years have passed since the initial discovery of this complex substance and, during this …

Heparin is a life-saving drug, which belongs to few clinically used drugs without defined
molecular structures in modern medicine. Heparin is the mostly negatively charged …

Affinity-fractionated porcine heparin was randomly scissioned by chemical techniques to
give hexasaccharides, octasaccharides, decasaccharides, and mucopolysaccharide …