Heparin inhibits blood coagulation by binding to the protease inhibitor antithrombin, thus
promoting inactivation of the protease “factors” of the coagulation cascade mechanism. The …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Heparin is a glycosaminoglycuran that is widely distributed in animal tissues. It is composed
of an alternating sequence of 2-amino-2-deoxy sugars and hexuronic acids,'usually …

Low molecular weight heparins from a variety of commercial sources were examined. These
had been prepared by several methods including peroxidative cleavage, nitrous acid …

Heparan sulfate (HS) is a complex and highly active biopolymer that is synthesized as an
alternating copolymer of hexuronic acid and glucosamine and modified at various positions …

Heparin has been widely used as an anticoagulant for more than 80 years. However, there
is now considerable evidence that heparin also possesses anti‐inflammatory activity, both …

The molecular basis for the anticoagulant action of heparin lies in its ability to bind to and
enhance the inhibitory activity of the plasma protein antithrombin against several serine …

In this report we describe a convenient and sensitive HPLC method for separating and
determining the non-and variously sulphated Δ-disaccharides derived from heparan …

Antithrombin is a protease inhibitor that neutralizes the activity of the serine proteases of the
coagulation cascade, such as factors IXa, Xa, XIa, XIIa, and thrombin by forming a 1: 1 …

Heparin-and heparan sulfate-like glycosaminoglycans (HLGAGs) represent an important
class of molecules that interact with and modulate the activity of growth factors, enzymes …